Identification and characterization of the high-affinity choline transporter

Takashi Okuda, Tatsuya Haga, Yoshikatsu Kanai, Hitoshi Endou, Takeshi Ishihara, Isao Katsura

研究成果: Article査読

256 被引用数 (Scopus)

抄録

In cholinergic neurons, high-affinity choline uptake in presynaptic terminals is the rate-limiting step in acetylcholine synthesis. Using information provided by the Caenorhabditis elegans Genome Project, we cloned a cDNA encoding the high-affinity choline transporter from C. elegans (cho- 1). We subsequently used this clone to isolate the corresponding cDNA from rat (CHT1). CHT1 is not homologous to neurotransmitter transporters, but is homologous to members of the Na+-dependent glucose transporter family. Expression of CHT1 mRNA is restricted to cholinergic neurons. The characteristics of CHT1-mediated choline uptake essentially match those of high-affinity choline uptake in rat brain synaptosomes.

本文言語English
ページ(範囲)120-125
ページ数6
ジャーナルNature Neuroscience
3
2
DOI
出版ステータスPublished - 2000 2
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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