Identification of a molecular target of kurahyne, an apoptosis-inducing lipopeptide from marine cyanobacterial assemblages

Arihiro Iwasaki, Osamu Ohno, Shun Katsuyama, Maho Morita, Yukiko Sasazawa, Shingo Dan, Siro Simizu, Takao Yamori, Kiyotake Suenaga

研究成果: Article査読

7 被引用数 (Scopus)

抄録

In 2014, we isolated kurahyne, an acetylene-containing lipopeptide, from a marine cyanobacterial assemblage of Lyngbya sp. Kurahyne exhibited growth-inhibitory activity against human cancer cells, and induced apoptosis in HeLa cells. However, its mode of action is not yet clear. To elucidate its mode of action, we carried out several cell-based assays, and identified the intracellular target molecule of kurahyne as sarco/endoplasmic reticulum Ca2+ ATPase (SERCA). In addition, we found that kurahyne inhibited the differentiation of macrophages into osteoclasts.

本文言語English
ページ(範囲)5295-5298
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
25
22
DOI
出版ステータスPublished - 2015 11 15

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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