Identification of a novel compound that inhibits osteoclastogenesis by suppressing nucleoside transporters

Shun Katsuyama, Kumi Sugino, Yukiko Sasazawa, Yoshihiko Nakano, Harumi Aono, Keisuke Morishita, Makoto Kawatani, Kazuo Umezawa, Hiroyuki Osada, Siro Simizu

研究成果: Article査読

9 被引用数 (Scopus)

抄録

We screened small-molecule compounds that inhibit osteoclast differentiation to find new anti-osteoporosis agents and found that a novel compound, SUKU-1, suppressed osteoclastogenesis. We also synthesized 38 derivatives of SUKU-1 and discovered that nine of them had inhibitory effects on osteoclastogenesis and that SUKU-33 was the most potent inhibitor. Next, we investigated the mechanisms by which SUKU-33 suppressed osteoclast differentiation. By measuring the uptake of [3H]-uridine in cells, we found that SUKU-33 suppressed both equilibrative nucleoside transporters and concentrative nucleoside transporters. These results suggest that SUKU-33 inhibits osteoclast differentiation by suppressing nucleoside transporters.

本文言語English
ページ(範囲)1152-1162
ページ数11
ジャーナルFEBS Letters
590
8
DOI
出版ステータスPublished - 2016 4月 1

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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