Identification of a novel human homolog of the Drosophila dlg, P-dlg, specifically expressed in the gland tissues and interacting with p55

Hideo Nakamura, Tamotsu Sudo, Hiromasa Tsuiki, Hideaki Miyake, Tetsuro Morisaki, Ji Ichiro Sasaki, Norio Masuko, Masato Kochi, Yukitaka Ushio, Hideyuki Saya

研究成果: Article査読

44 被引用数 (Scopus)

抄録

We have identified a novel human homolog of the Drosophila dlg tumor suppressor gene, termed P-dlg, which has been mapped at chromosome 10q23. Unlike other human dlg homologs, P-dlg is expressed in placenta and various gland tissues but not in brain. The P-dlg protein is localized at the plasma membrane and cytoplasm, and it is expressed in the gland epithelial cells in normal prostate tissue but not in prostate cancer cell lines. Furthermore, we identified interaction between P-dlg and p55 palmitoylated membrane protein by yeast two-hybrid screening. These findings suggest that P-dlg forms a complex with p55 at the plasma membrane and plays roles in maintaining the structure of epithelial cells and transmitting extracellular signals to the membrane and cytoskeleton, which may negatively regulate cell proliferation. Copyright (C) 1998 Federation of European Biochemical Societies.

本文言語English
ページ(範囲)63-67
ページ数5
ジャーナルFEBS Letters
433
1-2
DOI
出版ステータスPublished - 1998 8 14
外部発表はい

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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