Identification of lung inflammation-related elevation of acylamino acid releasing enzyme (APEH) activity using an enzymomics approach

Toru Komatsu, Kentaro Yoshioka, Kenjiro Hanaoka, Takuya Terai, Tasuku Ueno, Tetsuo Nagano, Yasuteru Urano

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Disease-associated alterations of enzymatic functions are potentially useful as disease biomarkers, and here we show that an enzymomics (omics of active enzymes) approach, in which enzymatic activities are screened with panels of substrates, can be an effective way to identify such alterations. In the present study, we used a panel of fluorogenic substrates to search for altered enzyme activities in bronchoalveolar lavage fluid (BALF) from a mouse model of lung inflammation. We found that acylamino acid releasing enzyme (APEH) activity was highly elevated, apparently reflecting the increased population of immune cells in the inflamed lung.

本文言語English
ページ(範囲)1533-1538
ページ数6
ジャーナルChemical and Pharmaceutical Bulletin
64
11
DOI
出版ステータスPublished - 2016
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)
  • 創薬

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