Identification of novel omega-3 fatty acid-derived bioactive metabolites based on a targeted lipidomics approach

Yosuke Isobe, Makoto Arita

研究成果: Review article査読

19 被引用数 (Scopus)

抄録

Omega-3 Polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid have beneficial effects in many inflammatory disorders. Although the mechanism of eicosapentaenoic acid and docosahexaenoic acid action is still not fully defined in molecular terms, recent studies have revealed that, during the course of acute inflammation, omega-3 polyunsaturated fatty acid-derived anti-inflammatory mediators including resolvins and protectins are produced. This review presents recent advances in understanding the formation and action of these mediators, especially focusing on the LC-MS/MS-based lipidomics approach and recently identified bioactive products with potent anti-inflammatory property.

本文言語English
ページ(範囲)79-84
ページ数6
ジャーナルJournal of Clinical Biochemistry and Nutrition
55
2
DOI
出版ステータスPublished - 2014
外部発表はい

ASJC Scopus subject areas

  • 医学(その他)
  • 栄養および糖尿病
  • 臨床生化学

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