Identification of the toxic trigger in mushroom poisoning

Masanori Matsuura, Yoko Saikawa, Kosei Inui, Koichi Nakae, Masayuki Igarashi, Kimiko Hashimoto, Masaya Nakata

研究成果: Article査読

49 被引用数 (Scopus)

抄録

We have isolated the small, highly strained carboxylic acid cycloprop-2-ene carboxylic acid from the Asian toxic mushroom Russula subnigricans. This compound is responsible for fatal rhabdomyolysis, a new type of mushroom poisoning that is indicated by an increase in serum creatine phosphokinase activity in mice. We found that polymerization of the compound at high concentrations via ene reaction abolishes its toxicity.

本文言語English
ページ(範囲)465-467
ページ数3
ジャーナルNature Chemical Biology
5
7
DOI
出版ステータスPublished - 2009 7

ASJC Scopus subject areas

  • 分子生物学
  • 細胞生物学

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