Identification of tumor antigens recognized by T cells and their use for analysis of anti-tumor responses

Tomonobu Fujita, Yutaka Kawakami

研究成果: Article

抄録

One of the problems in the development of immunotherapy in the past was poor evaluation of anti-tumor immune responses. Consequently, it was difficult to improve the immunotherapy. Various human tumor antigens recognized by T cells have recently been identified using various methods, including cDNA expression cloning with tumor reactive T cells and antibodies, as well as various cDNA subtraction methods in combination with in vitro T cell induction. The identification of tumor antigenic peptides recognized by T cells allows us to monitor anti-tumor T cell response quantitatively and qualitatively during immunotherapy as well as to develop more efficient immunotherapy with a sufficient amount of antigens in more immunogenic forms.

元の言語English
ページ(範囲)441-448
ページ数8
ジャーナルBiotherapy
16
発行部数5
出版物ステータスPublished - 2002 9

Fingerprint

Neoplasm Antigens
Immunotherapy
T-Lymphocytes
Neoplasms
Complementary DNA
Peptide T
Organism Cloning
Antigens
Antibodies

ASJC Scopus subject areas

  • Cancer Research
  • Immunology and Allergy

これを引用

Identification of tumor antigens recognized by T cells and their use for analysis of anti-tumor responses. / Fujita, Tomonobu; Kawakami, Yutaka.

:: Biotherapy, 巻 16, 番号 5, 09.2002, p. 441-448.

研究成果: Article

Fujita, Tomonobu ; Kawakami, Yutaka. / Identification of tumor antigens recognized by T cells and their use for analysis of anti-tumor responses. :: Biotherapy. 2002 ; 巻 16, 番号 5. pp. 441-448.
@article{e874a6dbcaf340c6bf370f2e2a12313e,
title = "Identification of tumor antigens recognized by T cells and their use for analysis of anti-tumor responses",
abstract = "One of the problems in the development of immunotherapy in the past was poor evaluation of anti-tumor immune responses. Consequently, it was difficult to improve the immunotherapy. Various human tumor antigens recognized by T cells have recently been identified using various methods, including cDNA expression cloning with tumor reactive T cells and antibodies, as well as various cDNA subtraction methods in combination with in vitro T cell induction. The identification of tumor antigenic peptides recognized by T cells allows us to monitor anti-tumor T cell response quantitatively and qualitatively during immunotherapy as well as to develop more efficient immunotherapy with a sufficient amount of antigens in more immunogenic forms.",
keywords = "CDNA expression cloning, HLA tetramer, Immunotherapy, T cell, Tumor antigens",
author = "Tomonobu Fujita and Yutaka Kawakami",
year = "2002",
month = "9",
language = "English",
volume = "16",
pages = "441--448",
journal = "Biotherapy",
issn = "0914-2223",
publisher = "Japanese Society for Cancer Chemotherapy",
number = "5",

}

TY - JOUR

T1 - Identification of tumor antigens recognized by T cells and their use for analysis of anti-tumor responses

AU - Fujita, Tomonobu

AU - Kawakami, Yutaka

PY - 2002/9

Y1 - 2002/9

N2 - One of the problems in the development of immunotherapy in the past was poor evaluation of anti-tumor immune responses. Consequently, it was difficult to improve the immunotherapy. Various human tumor antigens recognized by T cells have recently been identified using various methods, including cDNA expression cloning with tumor reactive T cells and antibodies, as well as various cDNA subtraction methods in combination with in vitro T cell induction. The identification of tumor antigenic peptides recognized by T cells allows us to monitor anti-tumor T cell response quantitatively and qualitatively during immunotherapy as well as to develop more efficient immunotherapy with a sufficient amount of antigens in more immunogenic forms.

AB - One of the problems in the development of immunotherapy in the past was poor evaluation of anti-tumor immune responses. Consequently, it was difficult to improve the immunotherapy. Various human tumor antigens recognized by T cells have recently been identified using various methods, including cDNA expression cloning with tumor reactive T cells and antibodies, as well as various cDNA subtraction methods in combination with in vitro T cell induction. The identification of tumor antigenic peptides recognized by T cells allows us to monitor anti-tumor T cell response quantitatively and qualitatively during immunotherapy as well as to develop more efficient immunotherapy with a sufficient amount of antigens in more immunogenic forms.

KW - CDNA expression cloning

KW - HLA tetramer

KW - Immunotherapy

KW - T cell

KW - Tumor antigens

UR - http://www.scopus.com/inward/record.url?scp=0036709717&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036709717&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0036709717

VL - 16

SP - 441

EP - 448

JO - Biotherapy

JF - Biotherapy

SN - 0914-2223

IS - 5

ER -