IFN-γ, produced by NK cells that infiltrate liver allografts early after transplantation, links the innate and adaptive immune responses

Hideaki Obara, Kazuhito Nagasaki, Christine L. Hsieh, Yasuhiro Ogura, Carlos O. Esquivel, Olivia M. Martinez, Sheri M. Krams

研究成果: Article査読

85 被引用数 (Scopus)

抄録

The role of NK cells following solid organ transplantation remains unclear. We examined NK cells in acute allograft rejection using a high responder model (DA → Lewis) of rat orthotopic liver transplantation. Recipient-derived NK cells infiltrated liver allografts early after transplantation. Since chemokines are important in the trafficking of cells to areas of inflammation, we determined the intragraft expression of chemokines known to attract NK cells. CCL3 was significantly increased in allografts at 6 h post-transplant as compared to syngeneic grafts whereas CCL2 and CXCL10 were elevated in both syngeneic and allogeneic grafts. CXCL10 and CX3CL1 were significantly upregulated in allografts by day 3 post-transplant as compared to syngeneic grafts suggesting a role for these chemokines in the recruitment of effector cells to allografts. Graft-infiltrating NK cells were shown to be a major source of IFN-γ, and IFN-γ levels in the serum were markedly increased, specifically in allograft recipients, by day 3 post-transplant. Accordingly, in the absence of NK cells the levels of IFN-γ were significantly decreased. Furthermore, graft survival was significantly prolonged. These data suggest that IFN-γ -producing NK cells are an important link between the innate and adaptive immune responses early after transplantation.

本文言語English
ページ(範囲)2094-2103
ページ数10
ジャーナルAmerican Journal of Transplantation
5
9
DOI
出版ステータスPublished - 2005 9月
外部発表はい

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 移植
  • 薬理学(医学)

フィンガープリント

「IFN-γ, produced by NK cells that infiltrate liver allografts early after transplantation, links the innate and adaptive immune responses」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル