IgG4-negative autoimmune pancreatitis with sclerosing cholangitis and colitis: Possible association with primary sclerosing cholangitis?

Keita Saeki, Shigenari Hozawa, Naoteru Miyata, Toshihiro Nishizawa, Hiromitsu Soma, Yasushi Iwao, Kaori Kameyama, Toshifumi Hibi

研究成果: Article

8 引用 (Scopus)

抄録

We report a case of autoimmune pancreatitis (AIP) with cholangiography and histopathology showing features characteristic of primary sclerosing cholangitis (PSC) and colitis. A 55-year-old previously-healthy man was diagnosed with anti-nuclear antibody (ANA)-positive AIP according to the finding of serum biochemistry, abdominal US (ultrasonography), CT (computed tomography) and ERCP (endoscopic retrograde cholangiopancreatography). However, bead-like strictures of intrahepatic bile ducts were also found and liver tissue showed onion skin-like periductal fibrosis but no anti-IgG4-positive cells. In addition, colon fiberscopy showed a pancolitis similar to ulcerative colitis indicating that, in this case, there may be an association with PSC. Here, we report a rare case of IgG4-negative AIP with sclerosing cholangitis and colitis with many clinical features that support an association with PSC.

元の言語English
ページ(範囲)943-948
ページ数6
ジャーナルInternal Medicine
47
発行部数10
DOI
出版物ステータスPublished - 2008

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Sclerosing Cholangitis
Colitis
Pancreatitis
Immunoglobulin G
Intrahepatic Bile Ducts
Onions
Cholangiography
Endoscopic Retrograde Cholangiopancreatography
Ulcerative Colitis
Biochemistry
Anti-Idiotypic Antibodies
Ultrasonography
Pathologic Constriction
Colon
Fibrosis
Tomography
Skin
Liver
Serum

ASJC Scopus subject areas

  • Internal Medicine
  • Medicine(all)

これを引用

IgG4-negative autoimmune pancreatitis with sclerosing cholangitis and colitis : Possible association with primary sclerosing cholangitis? / Saeki, Keita; Hozawa, Shigenari; Miyata, Naoteru; Nishizawa, Toshihiro; Soma, Hiromitsu; Iwao, Yasushi; Kameyama, Kaori; Hibi, Toshifumi.

:: Internal Medicine, 巻 47, 番号 10, 2008, p. 943-948.

研究成果: Article

Saeki, Keita ; Hozawa, Shigenari ; Miyata, Naoteru ; Nishizawa, Toshihiro ; Soma, Hiromitsu ; Iwao, Yasushi ; Kameyama, Kaori ; Hibi, Toshifumi. / IgG4-negative autoimmune pancreatitis with sclerosing cholangitis and colitis : Possible association with primary sclerosing cholangitis?. :: Internal Medicine. 2008 ; 巻 47, 番号 10. pp. 943-948.
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abstract = "We report a case of autoimmune pancreatitis (AIP) with cholangiography and histopathology showing features characteristic of primary sclerosing cholangitis (PSC) and colitis. A 55-year-old previously-healthy man was diagnosed with anti-nuclear antibody (ANA)-positive AIP according to the finding of serum biochemistry, abdominal US (ultrasonography), CT (computed tomography) and ERCP (endoscopic retrograde cholangiopancreatography). However, bead-like strictures of intrahepatic bile ducts were also found and liver tissue showed onion skin-like periductal fibrosis but no anti-IgG4-positive cells. In addition, colon fiberscopy showed a pancolitis similar to ulcerative colitis indicating that, in this case, there may be an association with PSC. Here, we report a rare case of IgG4-negative AIP with sclerosing cholangitis and colitis with many clinical features that support an association with PSC.",
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AU - Saeki, Keita

AU - Hozawa, Shigenari

AU - Miyata, Naoteru

AU - Nishizawa, Toshihiro

AU - Soma, Hiromitsu

AU - Iwao, Yasushi

AU - Kameyama, Kaori

AU - Hibi, Toshifumi

PY - 2008

Y1 - 2008

N2 - We report a case of autoimmune pancreatitis (AIP) with cholangiography and histopathology showing features characteristic of primary sclerosing cholangitis (PSC) and colitis. A 55-year-old previously-healthy man was diagnosed with anti-nuclear antibody (ANA)-positive AIP according to the finding of serum biochemistry, abdominal US (ultrasonography), CT (computed tomography) and ERCP (endoscopic retrograde cholangiopancreatography). However, bead-like strictures of intrahepatic bile ducts were also found and liver tissue showed onion skin-like periductal fibrosis but no anti-IgG4-positive cells. In addition, colon fiberscopy showed a pancolitis similar to ulcerative colitis indicating that, in this case, there may be an association with PSC. Here, we report a rare case of IgG4-negative AIP with sclerosing cholangitis and colitis with many clinical features that support an association with PSC.

AB - We report a case of autoimmune pancreatitis (AIP) with cholangiography and histopathology showing features characteristic of primary sclerosing cholangitis (PSC) and colitis. A 55-year-old previously-healthy man was diagnosed with anti-nuclear antibody (ANA)-positive AIP according to the finding of serum biochemistry, abdominal US (ultrasonography), CT (computed tomography) and ERCP (endoscopic retrograde cholangiopancreatography). However, bead-like strictures of intrahepatic bile ducts were also found and liver tissue showed onion skin-like periductal fibrosis but no anti-IgG4-positive cells. In addition, colon fiberscopy showed a pancolitis similar to ulcerative colitis indicating that, in this case, there may be an association with PSC. Here, we report a rare case of IgG4-negative AIP with sclerosing cholangitis and colitis with many clinical features that support an association with PSC.

KW - Autoimmune pancreatitis

KW - Cholangitis

KW - Colitis

KW - Primary sclerosing cholangitis

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