Ikoamide, an Antimalarial Lipopeptide from an Okeania sp. Marine Cyanobacterium

Keitaro Iwasaki, Arihiro Iwasaki, Shimpei Sumimoto, Teruhiko Matsubara, Toshinori Sato, Tomoyoshi Nozaki, Yumiko Saito-Nakano, Kiyotake Suenaga

研究成果: Article査読

6 被引用数 (Scopus)

抄録

An antimalarial lipopeptide, ikoamide, was isolated from an Okeania sp. marine cyanobacterium. Its gross structure was established by spectroscopic analyses, and the absolute configuration was clarified based on a combination of chiral-phase HPLC analyses, spectroscopic analyses, and derivatization reactions. Ikoamide showed strong antimalarial activity with an IC50 value of 0.14 μM without cytotoxicity against human cancer cell lines at 10 μM.

本文言語English
ページ(範囲)481-488
ページ数8
ジャーナルJournal of Natural Products
83
2
DOI
出版ステータスPublished - 2020 2 28

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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