IL-10-producing CD4+ T cells negatively regulate fucosylation of epithelial cells in the gut

Yoshiyuki Goto, Aayam Lamichhane, Mariko Kamioka, Shintaro Sato, Kenya Honda, Jun Kunisawa, Hiroshi Kiyono

研究成果: Article査読

20 被引用数 (Scopus)

抄録

Fucosylated glycans on the surface of epithelial cells (ECs) regulate intestinal homeostasis by serving as attachment receptors and a nutrient source for some species of bacteria. We show here that epithelial fucosylation in the ileum is negatively regulated by IL-10-producing CD4+ T cells. The number of fucosylated ECs was increased in the ileum of mice lacking T cells, especially those expressing αβ T cell receptor (TCR), CD4, and IL-10. No such effect was observed in mice lacking B cells. Adoptive transfer of αβTCR + CD4+ T cells from normal mice, but not IL-10-deficient mice, normalized fucosylation of ECs. These findings suggest that IL-10-producing CD4+ T cells contribute to the maintenance of the function of ECs by regulating their fucosylation.

本文言語English
論文番号15918
ジャーナルScientific reports
5
DOI
出版ステータスPublished - 2015 11 2
外部発表はい

ASJC Scopus subject areas

  • 一般

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