IL-6 and related cytokines as the critical lynchpins between inflammation and cancer

Koji Taniguchi, Michael Karin

研究成果: Review article査読

408 被引用数 (Scopus)

抄録

Inflammatory responses play pivotal roles in cancer development, including tumor initiation, promotion, progression, and metastasis. Cytokines are now recognized as important mediators linking inflammation and cancer, and are therefore potential therapeutic and preventive targets as well as prognostic factors. The interleukin (IL)-6 family of cytokines, especially IL-6 and IL-11, is highly up-regulated in many cancers and considered as one of the most important cytokine families during tumorigenesis and metastasis. This review discusses molecular mechanisms linking the IL-6 cytokine family to solid malignancies and their treatment.

本文言語English
ページ(範囲)54-74
ページ数21
ジャーナルSeminars in Immunology
26
1
DOI
出版ステータスPublished - 2014 2月
外部発表はい

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学

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