IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

Hideo Yasukawa, Masanobu Ohishi, Hiroyuki Mori, Masaaki Murakami, Takatoshi Chinen, Daisuke Aki, Toshikatsu Hanada, Kiyoshi Takeda, Shizuo Akira, Masahiko Hoshijima, Toshio Hirano, Kenneth R. Chien, Akihiko Yoshimura

研究成果: Article

541 引用 (Scopus)

抄録

Whereas interleukin-6 (IL-6) is a proinflammatory cytokine, IL-10 is an anti-inflammatory cytokine. Although signal transducer and activator of transcription 3 (STAT3) is essential for the function of both IL-6 and IL-10, it is unclear how these two cytokines have such opposing functions. Here we show that suppressor of cytokine signaling 3 (SOCS3) is a key regulator of the divergent action of these two cytokines. In macrophages lacking the Socs3 gene or carrying a mutation of the SOCS3-binding site in gp130, the lipopolysaccharide-induced production of tumor necrosis factor (TNF) and IL-12 is suppressed by both IL-10 and IL-6. SOCS3 specifically prevents activation of STAT3 by IL-6 but not IL-10. Taken together, these data indicate that SOCS3 selectively blocks signaling by IL-6, thereby preventing its ability to inhibit LPS signaling.

元の言語English
ページ(範囲)551-556
ページ数6
ジャーナルNature Immunology
4
発行部数6
DOI
出版物ステータスPublished - 2003 6 1
外部発表Yes

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Interleukin-6
Anti-Inflammatory Agents
Macrophages
Cytokines
Interleukin-10
STAT3 Transcription Factor
Genetic Suppression
Interleukin-12
Lipopolysaccharides
Tumor Necrosis Factor-alpha
Binding Sites
Genes

ASJC Scopus subject areas

  • Immunology

これを引用

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. / Yasukawa, Hideo; Ohishi, Masanobu; Mori, Hiroyuki; Murakami, Masaaki; Chinen, Takatoshi; Aki, Daisuke; Hanada, Toshikatsu; Takeda, Kiyoshi; Akira, Shizuo; Hoshijima, Masahiko; Hirano, Toshio; Chien, Kenneth R.; Yoshimura, Akihiko.

:: Nature Immunology, 巻 4, 番号 6, 01.06.2003, p. 551-556.

研究成果: Article

Yasukawa, H, Ohishi, M, Mori, H, Murakami, M, Chinen, T, Aki, D, Hanada, T, Takeda, K, Akira, S, Hoshijima, M, Hirano, T, Chien, KR & Yoshimura, A 2003, 'IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages', Nature Immunology, 巻. 4, 番号 6, pp. 551-556. https://doi.org/10.1038/ni938
Yasukawa, Hideo ; Ohishi, Masanobu ; Mori, Hiroyuki ; Murakami, Masaaki ; Chinen, Takatoshi ; Aki, Daisuke ; Hanada, Toshikatsu ; Takeda, Kiyoshi ; Akira, Shizuo ; Hoshijima, Masahiko ; Hirano, Toshio ; Chien, Kenneth R. ; Yoshimura, Akihiko. / IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. :: Nature Immunology. 2003 ; 巻 4, 番号 6. pp. 551-556.
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