Immune and Inflammatory Networks in Myocardial Infarction: Current Research and Its Potential Implications for the Clinic

研究成果: Review article査読

1 被引用数 (Scopus)

抄録

Despite recent scientific and technological advances, myocardial infarction (MI) still repre-sents a major global health problem, leading to high morbidity and mortality worldwide. During the post-MI wound healing process, dysregulated immune inflammatory pathways and failure to resolve inflammation are associated with maladaptive left ventricular remodeling, progressive heart failure, and eventually poor outcomes. Given the roles of immune cells in the host response against tissue injury, understanding the involved cellular subsets, sources, and functions is essential for discovering novel therapeutic strategies that preserve the protective immune system and promote optimal healing. This review discusses the cellular effectors and molecular signals across multi-organ systems, which regulate the inflammatory and reparative responses after MI. Additionally, we summarize the recent clinical and preclinical data that propel conceptual revolutions in cardiovascular immunotherapy.

本文言語English
論文番号5214
ジャーナルInternational journal of molecular sciences
23
9
DOI
出版ステータスPublished - 2022 5月 1

ASJC Scopus subject areas

  • 触媒
  • 分子生物学
  • 分光学
  • コンピュータ サイエンスの応用
  • 物理化学および理論化学
  • 有機化学
  • 無機化学

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