Immune aspects of the pathogenesis of inflammatory bowel disease

Tadakazu Hisamatsu, Takanori Kanai, Yohei Mikami, Kazuaki Yoneno, Katsuyoshi Matsuoka, Toshifumi Hibi

研究成果: Review article査読

64 被引用数 (Scopus)

抄録

Although the precise etiologies of inflammatory bowel disease (IBD) (ulcerative colitis and Crohn's disease) remain obscure, several reports have indicated that dysfunction of the mucosal immune system plays an important role in its pathogenesis. Recent progress with genome-wide association studies has identified many IBD susceptibility genes. In individuals with genetic risk, abnormal interactions between the host immune system and gut flora, and dysregulation of cellular responses such as autophagy and ER stress, induce an abnormal host immune response in the gut resulting in intestinal inflammation. Research progress animal models in IBD, and in human IBD, has identified several key molecules in IBD pathogenesis such as TNFα and adhesion molecules, and molecular targeting therapies based on these molecules have been developed. Here, we review immunological aspects in IBD pathogenesis and the development of immunoregulatory therapy.

本文言語English
ページ(範囲)283-297
ページ数15
ジャーナルPharmacology and Therapeutics
137
3
DOI
出版ステータスPublished - 2013 3 1

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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