Immune-mediated neuropathy with anti-disialosyl IgM antibodies in diffuse large B-cell lymphoma: A case report and literature review

Gen Shihashi, Takuya Yagi, Shigeaki Suzuki, Morinobu Seki, Sumiko Kohashi, Tomoki Ueda, Kaori Kameyama, Susumu Kusunoki, Hideaki Nakajima, Shinichiro Okamoto, Norihiro Suzuki

研究成果: Article

2 引用 (Scopus)

抄録

A 36-year-old man with diffuse large B-cell lymphoma presented with polyneuropathy, and the diagnostic work-up revealed the presence of IgM antibodies against gangliosides with disialosyl residues (GD1b, GD3). He was treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone and received high-dose intravenous immunoglobulin for the treatment of neuropathy. After initiating the treatments, the patient's neurological impairment improved dramatically. He currently remains in complete remission without a flare-up of the polyneuropathy. Based upon our experience and other case reports of lymphoma with immune-mediated neuropathy caused by anti-disialosyl ganglioside IgM antibodies, we conclude that determining the anti-ganglioside antibody profile and beginning early treatment should be considered promptly for patients with malignant lymphoma who develop polyneuropathy.

元の言語English
ページ(範囲)1647-1651
ページ数5
ジャーナルInternal Medicine
54
発行部数13
DOI
出版物ステータスPublished - 2015 7 1

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Lymphoma, Large B-Cell, Diffuse
Polyneuropathies
Gangliosides
Immunoglobulin M
Antibodies
Lymphoma
Intravenous Immunoglobulins
Vincristine
Prednisone
Doxorubicin
Cyclophosphamide
Anti-Idiotypic Antibodies
Therapeutics
anti-IgM

ASJC Scopus subject areas

  • Internal Medicine

これを引用

Immune-mediated neuropathy with anti-disialosyl IgM antibodies in diffuse large B-cell lymphoma : A case report and literature review. / Shihashi, Gen; Yagi, Takuya; Suzuki, Shigeaki; Seki, Morinobu; Kohashi, Sumiko; Ueda, Tomoki; Kameyama, Kaori; Kusunoki, Susumu; Nakajima, Hideaki; Okamoto, Shinichiro; Suzuki, Norihiro.

:: Internal Medicine, 巻 54, 番号 13, 01.07.2015, p. 1647-1651.

研究成果: Article

Shihashi, Gen ; Yagi, Takuya ; Suzuki, Shigeaki ; Seki, Morinobu ; Kohashi, Sumiko ; Ueda, Tomoki ; Kameyama, Kaori ; Kusunoki, Susumu ; Nakajima, Hideaki ; Okamoto, Shinichiro ; Suzuki, Norihiro. / Immune-mediated neuropathy with anti-disialosyl IgM antibodies in diffuse large B-cell lymphoma : A case report and literature review. :: Internal Medicine. 2015 ; 巻 54, 番号 13. pp. 1647-1651.
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AU - Seki, Morinobu

AU - Kohashi, Sumiko

AU - Ueda, Tomoki

AU - Kameyama, Kaori

AU - Kusunoki, Susumu

AU - Nakajima, Hideaki

AU - Okamoto, Shinichiro

AU - Suzuki, Norihiro

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AB - A 36-year-old man with diffuse large B-cell lymphoma presented with polyneuropathy, and the diagnostic work-up revealed the presence of IgM antibodies against gangliosides with disialosyl residues (GD1b, GD3). He was treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone and received high-dose intravenous immunoglobulin for the treatment of neuropathy. After initiating the treatments, the patient's neurological impairment improved dramatically. He currently remains in complete remission without a flare-up of the polyneuropathy. Based upon our experience and other case reports of lymphoma with immune-mediated neuropathy caused by anti-disialosyl ganglioside IgM antibodies, we conclude that determining the anti-ganglioside antibody profile and beginning early treatment should be considered promptly for patients with malignant lymphoma who develop polyneuropathy.

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