Immune-resistant mechanisms in cancer immunotherapy

Yutaka Kawakami, Shigeki Ohta, Mohammad A. Sayem, Nobuo Tsukamoto, Tomonori Yaguchi

研究成果: Review article査読

6 被引用数 (Scopus)

抄録

Immune checkpoint inhibitors (ICI) such as PD-1/PD-L1 antibodies (Abs) and CTLA4 Abs and T cell-based adoptive cell therapies are effective for patients with various cancers. However, response rates of ICI monotherapies are still limited due to lack of immunogenic antigens and various immune-resistant mechanisms. The latter includes adaptive immune resistance that is caused by anti-tumor T cells (e.g. PD-L1 induced by IFN-γ from T cells) and primary immune resistance that is caused by cancer cells (e.g. immunosuppressive cytokines produced by cancer cells). Further understanding of the immune-resistant mechanisms, which may be possible through comparative analyses of responders and non-responders to the immunotherapies, will lead to the identification of new diagnostic biomarkers and therapeutic targets for development of effective cancer immuno therapies.

本文言語English
ページ(範囲)810-817
ページ数8
ジャーナルInternational Journal of Clinical Oncology
25
5
DOI
出版ステータスPublished - 2020 5 1

ASJC Scopus subject areas

  • Surgery
  • Hematology
  • Oncology

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