Immunochemotherapy prevents human colon cancer metastasis after orthotopic onplantation of histologically-intact tumor tissue in nude mice

Toshiharu Furukawa, T. Kubota, M. Watanabe, T. H. Kuo, S. Kase, Y. Saikawa, H. Tanino, T. Teramoto, K. Ishibiki, M. Kitajima, R. M. Hoffman

研究成果: Article

13 引用 (Scopus)

抄録

A metastatic model of human colon cancer has been previously established using orthotopic onplantation of histologically intact in tissue nude mice. In this study, effects of immunochemotherapy using OK-432, 5-fluorouracil (5-FU) and mitomycin C (MMC) on Col-2-JCK, a human colon cancer xenograft, were evaluated using this model. When 5-FU and MMC were administered without OK-432, liver metastases were not reduced even at maximum tolerated doses of both drugs, although cecal tumor growth was significantly reduced. On the other hand, when combined with OK-432, both 5-FU and MMC reduced liver metastases with synergistic reduction of cecal tumor growth, demonstrating the potential of combining immunotherapy with chemotherapy against metastases.

元の言語English
ページ(範囲)287-291
ページ数5
ジャーナルAnticancer Research
13
発行部数2
出版物ステータスPublished - 1993

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Picibanil
Mitomycin
Nude Mice
Fluorouracil
Colonic Neoplasms
Neoplasm Metastasis
Neoplasms
Maximum Tolerated Dose
Liver
Growth
Heterografts
Immunotherapy
Drug Therapy
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

これを引用

Immunochemotherapy prevents human colon cancer metastasis after orthotopic onplantation of histologically-intact tumor tissue in nude mice. / Furukawa, Toshiharu; Kubota, T.; Watanabe, M.; Kuo, T. H.; Kase, S.; Saikawa, Y.; Tanino, H.; Teramoto, T.; Ishibiki, K.; Kitajima, M.; Hoffman, R. M.

:: Anticancer Research, 巻 13, 番号 2, 1993, p. 287-291.

研究成果: Article

Furukawa, T, Kubota, T, Watanabe, M, Kuo, TH, Kase, S, Saikawa, Y, Tanino, H, Teramoto, T, Ishibiki, K, Kitajima, M & Hoffman, RM 1993, 'Immunochemotherapy prevents human colon cancer metastasis after orthotopic onplantation of histologically-intact tumor tissue in nude mice', Anticancer Research, 巻. 13, 番号 2, pp. 287-291.
Furukawa, Toshiharu ; Kubota, T. ; Watanabe, M. ; Kuo, T. H. ; Kase, S. ; Saikawa, Y. ; Tanino, H. ; Teramoto, T. ; Ishibiki, K. ; Kitajima, M. ; Hoffman, R. M. / Immunochemotherapy prevents human colon cancer metastasis after orthotopic onplantation of histologically-intact tumor tissue in nude mice. :: Anticancer Research. 1993 ; 巻 13, 番号 2. pp. 287-291.
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abstract = "A metastatic model of human colon cancer has been previously established using orthotopic onplantation of histologically intact in tissue nude mice. In this study, effects of immunochemotherapy using OK-432, 5-fluorouracil (5-FU) and mitomycin C (MMC) on Col-2-JCK, a human colon cancer xenograft, were evaluated using this model. When 5-FU and MMC were administered without OK-432, liver metastases were not reduced even at maximum tolerated doses of both drugs, although cecal tumor growth was significantly reduced. On the other hand, when combined with OK-432, both 5-FU and MMC reduced liver metastases with synergistic reduction of cecal tumor growth, demonstrating the potential of combining immunotherapy with chemotherapy against metastases.",
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AU - Furukawa, Toshiharu

AU - Kubota, T.

AU - Watanabe, M.

AU - Kuo, T. H.

AU - Kase, S.

AU - Saikawa, Y.

AU - Tanino, H.

AU - Teramoto, T.

AU - Ishibiki, K.

AU - Kitajima, M.

AU - Hoffman, R. M.

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AB - A metastatic model of human colon cancer has been previously established using orthotopic onplantation of histologically intact in tissue nude mice. In this study, effects of immunochemotherapy using OK-432, 5-fluorouracil (5-FU) and mitomycin C (MMC) on Col-2-JCK, a human colon cancer xenograft, were evaluated using this model. When 5-FU and MMC were administered without OK-432, liver metastases were not reduced even at maximum tolerated doses of both drugs, although cecal tumor growth was significantly reduced. On the other hand, when combined with OK-432, both 5-FU and MMC reduced liver metastases with synergistic reduction of cecal tumor growth, demonstrating the potential of combining immunotherapy with chemotherapy against metastases.

KW - Colon cancer

KW - Immunotherapy

KW - Metastasis

KW - Nude mice

KW - Onplantation

KW - Orthotopic

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