Immunochemotherapy prevents human colon cancer metastasis after orthotopic onplantation of histologically-intact tumor tissue in nude mice

T. Furukawa, T. Kubota, M. Watanabe, T. H. Kuo, S. Kase, Yoshirou Saikawa, H. Tanino, T. Teramoto, K. Ishibiki, M. Kitajima, R. M. Hoffman

研究成果: Article

13 引用 (Scopus)

抜粋

A metastatic model of human colon cancer has been previously established using orthotopic onplantation of histologically intact in tissue nude mice. In this study, effects of immunochemotherapy using OK-432, 5-fluorouracil (5-FU) and mitomycin C (MMC) on Col-2-JCK, a human colon cancer xenograft, were evaluated using this model. When 5-FU and MMC were administered without OK-432, liver metastases were not reduced even at maximum tolerated doses of both drugs, although cecal tumor growth was significantly reduced. On the other hand, when combined with OK-432, both 5-FU and MMC reduced liver metastases with synergistic reduction of cecal tumor growth, demonstrating the potential of combining immunotherapy with chemotherapy against metastases.

元の言語English
ページ(範囲)287-291
ページ数5
ジャーナルAnticancer research
13
発行部数2
出版物ステータスPublished - 1993 1 1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

フィンガープリント Immunochemotherapy prevents human colon cancer metastasis after orthotopic onplantation of histologically-intact tumor tissue in nude mice' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Furukawa, T., Kubota, T., Watanabe, M., Kuo, T. H., Kase, S., Saikawa, Y., Tanino, H., Teramoto, T., Ishibiki, K., Kitajima, M., & Hoffman, R. M. (1993). Immunochemotherapy prevents human colon cancer metastasis after orthotopic onplantation of histologically-intact tumor tissue in nude mice. Anticancer research, 13(2), 287-291.