Immunohistochemical and gene rearrangement studies of central nervous system lymphomatoid granulomatosis

Hiroshi Nishihara, Ukihide Tateishi, Tomoo Itoh, Kazuo Nagashima, Shinya Tanaka

研究成果: Article

28 引用 (Scopus)

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Lymphomatoid granulomatosis (LYG) is a rare multisystem disorder with characteristic angiocentric lymphoproliferative features, most frequently involving the lung, skin, and rarely the CNS. LYG has been classified into three subtypes based on the relative proportions of atypical and inflammatory infiltrating cells. Most systemic LYGs have been shown to be EBV-associated, T-cell rich, B-cell proliferative disorders. Here, we present four cases of LYG arising from the CNS and have analyzed them by immunohistochemistry to assess the phenotype of the infiltrate, and by PCR-SSCP (single-strand conformation polymorphism) analysis for immunoglobulin heavy chain (IgH) and T-cell receptor (TcR) γ gene rearrangements. Three cases revealed perivascular infiltration of T-cell dominant lymphoid cells, two cases showed monoclonal TcRγ gene rearrangement, while the remaining case had a B-cell immunophenotype and monoclonal IgH gene rearrangement with EBV genome expression. This is the first report of a gene rearrangement study on CNS-LYG. We confirm that some cases of CNS-LYG are derived from T-cell monoclonal lymphoproliferative disease, although this disease should be classified as a borderline malignancy and should be separated from overt malignant lymphoma of CNS.

元の言語English
ページ(範囲)413-418
ページ数6
ジャーナルNeuropathology
27
発行部数5
DOI
出版物ステータスPublished - 2007 10 1
外部発表Yes

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology

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