Immunohistochemical determination of immunosuppressive acidic protein in reactive and neoplastic diseases of macrophage

Katsuyuki Aozasa, Takafumi Ueda, Masahiro Ayata, Masahiko Tsujimoto, Masaki Q. Fujita, Teiichi Yamamura, Takahiro Tsujimura

研究成果: Article

12 引用 (Scopus)

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Immunosuppressive acidic protein (IAP), a substance purified from cancer ascitic fluid, is released into the culture medium of macrophages and neutrophils, and is supposed to suppress an immune function of the host. Elevation of serum IAP in cancer patients has been reported. In the current study, presence of IAP in proliferating diseases of macrophage was examined. Macrophages in reactive proliferation, histiocytosis X, and neoplastic proliferation gave positive reaction for IAP. Diffuse cytoplasmic staining was usual, but dot‐like or globular and surface staining also were observed. Proliferating cells in malignant fibrous histiocytoma were more sensitively stained by IAP than by other ordinary used markers for macrophage. These findings provide useful information to understand the mechanism of elevation of serum IAP in cancer patients.

元の言語English
ページ(範囲)2424-2427
ページ数4
ジャーナルCancer
60
発行部数10
DOI
出版物ステータスPublished - 1987 11 15
外部発表Yes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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