Immunohistochemical molecular expression profile of metastatic brain tumor for potent personalized medicine

Yasutaka Kato, Hiroshi Nishihara, Sayaka Yuzawa, Hiromi Mohri, Hiromi Kanno, Yutaka Hatanaka, Taichi Kimura, Mishie Tanino, Shinya Tanaka

研究成果: Article査読

4 被引用数 (Scopus)


Recent progress in molecule-targeting therapy may yield personalized therapeutic strategies for patients with metastatic brain tumors (MBT), the most frequently encountered intracranial tumors. For this purpose, we investigated the molecular expression profile of MBT to establish the pathological basis for personalized diagnosis. We studied 166 MBT specimens including 70 cases of lung cancer and 34 cases of breast cancer, and performed immunostaining for EGFR, COX-2, and O-6-methylguanine-DNA methyltransferase (MGMT), among others, which could be target molecules for therapeutic agents or enable prediction of drug efficacy. Loss of MGMT expression was observed in approximately 20-40 % of MBT derived from lung, breast, and gastrointestinal cancers, indicating the possibility of treatment of MBT patients with temozolomide. In addition, MBT expressed a variety of receptor tyrosine kinases, for example EGFR and HER2, and signal transduction molecules, for example phospho-mTOR and COX-2, irrespective of tumor origin, enabling individualized medication with molecule-targeting drugs. We also identified alteration of molecular expression profile in 4 MBT cases during recurrence. Our results not only reveal the molecular characteristics of MBT but also suggest the possibility of potent personalized medicine for MBT patients.

ジャーナルBrain tumor pathology
出版ステータスPublished - 2013 7月

ASJC Scopus subject areas

  • 腫瘍学
  • 臨床神経学
  • 癌研究


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