Immunohistochemical studies on mouse cerebral cortex grafted into the third ventricle of rats treated with cyclosporin A

Hiroshi Inoue, Shinichi Kohsaka, Kazunari Yoshida, Mitsuhiro Otani, Shigeo Toya, Yasuzo Tsukada

研究成果: Article査読

18 被引用数 (Scopus)

抄録

Newborn mouse cerebral cortex was transplanted into the third ventricle of an adult rat brain. After the operation, the immunosuppressant cyclosporin A was administered daily for two weeks, and the grafted tissue was examined immunohistochemically at the 4th week. Neurons, astroglias and oligoden-droglias were positively stained by antibodies against neurofilament, glial fibrillary acid protein and 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), respectively. The CNPase staining indicated that myelination had occurred in the grafted tissue. Thus both neuronal and glial elements in the grafted tissue could survive and mature in the third ventricle of the different species upon administration of cyclosporin A.

本文言語English
ページ(範囲)289-294
ページ数6
ジャーナルNeuroscience Letters
57
3
DOI
出版ステータスPublished - 1985 6 24

ASJC Scopus subject areas

  • 神経科学(全般)

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