Immunohistochemical study on the infection of herpes simplex virus, human cytomegalovirus, and Epstein-Barr virus in secondary diffuse interstitial pneumonia

Yoshio Oda, Yasunori Okada, Shogo Katsuda, Isao Nakanishi

研究成果: Article査読

17 被引用数 (Scopus)

抄録

We examined the infection of herpes simples virus (HSV), human cytomegalovirus (HCMV), and Epstein-Barr virus (EBV) in 61 autopsy cases with secondary diffuse interstitial pneumonia (SDIP) by immunohistochemistry and compared our findings with those in 46 individuals without lung complications. There was no significant difference in positivity of HSV infection between SDIP cases (28 of 61; 45.9%) and the controls (24 of 46; 52.2%). However, HSV was more extensively distributed in the lungs of seven SDIP cases than in those of controls and proliferated to form inclusion bodies in host cells of 11 SDIP cases. Twenty-two (36.1%) and 19 (31.1%) SDIP cases were positive for HCMV and EBV, respectively, whereas all the 46 controls were negative for both viruses. Eighteen of 22 HCMV-positive cases contained classical inclusion bodies in host cells. Epstein-Barr virus was detected extensively in the lungs of seven SDIP patients, but no viral inclusion bodies were observed in host cells. These findings indicate that the herpes viruses replicate excessively in a considerable number of SDIP cases, but classical inclusion bodies are not always associated with viral infection in the lungs. Major infected cells of these viruses were alveolar lining pneumocytes and intra-alveolar cells. Herpes simplex virus and EBV were detected in leukocytes as well as in pneumocytes. In addition, compared with HCMV and HSV, EBV frequently multiplied in bronchial or bronchiolar epithelial cells. Preferential host cells for these types of herpes virus were somewhat different from one another.

本文言語English
ページ(範囲)1057-1062
ページ数6
ジャーナルHuman Pathology
25
10
DOI
出版ステータスPublished - 1994 10月
外部発表はい

ASJC Scopus subject areas

  • 病理学および法医学

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