Immunologic rejection of the central graft after limbal allograft transplantation combined with penetrating keratoplasty

Jun Shimazaki, Fumiko Maruyama, Shigeto Shimmura, Hiroshi Fujishima, Kazuo Tsubota

研究成果: Article査読

48 被引用数 (Scopus)

抄録

Purpose. To study the incidence and prognosis of immunologic rejection of the central graft after limbal allograft transplantation (keratolimbal allograft transplantation [KLAT]) combined with penetrating keratoplasty (PKP). Methods. Endothelial rejection in central penetrating graft after simultaneous KLAT and PKP using the same donor cornea was retrospectively studied. Incidence, reversibility, prognosis, and changes in limbal grafts were examined. Results. Forty-five eyes underwent simultaneous PKP and KLAT. Endothelial rejection of the central graft was found in 16 eyes (35.6%). At last examination, 10 grafts (62.5%) restored clarity after immunosuppressive therapy. During rejection episodes, four eyes showed engorgement of vessels in limbal grafts, which existed before the episodes. Only one eye developed neovascularization with mild edema of the limbal grafts; however, no other limbal grafts showed abnormalities on biomicroscopy. No epithelial changes were noted, and 14 grafts (87.5%) were covered by corneal epithelium after the rejection. Conclusion. Approximately one third of eyes had endothelial rejection in the central graft after simultaneous KLAT and PKP. Abnormalities suggestive of rejection in the limbal grafts were seldom observed in these eyes, suggesting that immunologic response was different in central and limbal grafts.

本文言語English
ページ(範囲)149-152
ページ数4
ジャーナルCornea
20
2
DOI
出版ステータスPublished - 2001 3 6
外部発表はい

ASJC Scopus subject areas

  • 眼科学

フィンガープリント

「Immunologic rejection of the central graft after limbal allograft transplantation combined with penetrating keratoplasty」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル