Immunological abnormalities

Hidekata Yasuoka, Masataka Kuwana

研究成果: Chapter

抄録

The pathogenesis of Behçet's disease (BD) is still unclear. Both genetic and environmental factors contribute to the onset of BD, although immunological abnormalities are thought to play an important role. Genetics are responsible for autoinflammation and an underlying immunological condition, while the activation of innate and adaptive immune systems are triggered by environmental factors such as bacterial or viral infections. Underlying immunological abnormalities can lead to a unique expression profile of cytokines associated with Th1 or Th17 and induce both cytotoxicity and neutrophil-dependent inflammation, which are involved in the pathogenesis of BD.

本文言語English
ホスト出版物のタイトルBehçet's Disease
ホスト出版物のサブタイトルProgress in Recent Years and Unmet Needs for the Future
出版社Nova Science Publishers, Inc.
ページ23-37
ページ数15
ISBN(電子版)9781634829410
ISBN(印刷版)9781634828932
出版ステータスPublished - 2015 7月 1

ASJC Scopus subject areas

  • 医学(全般)

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