Immunological detection of altered signaling molecules involved in melanoma development

Yutaka Kawakami, Hidetoshi Sumimoto, Tomonobu Fujita, Yuriko Matsuzaki

研究成果: Article

9 引用 (Scopus)

抄録

To understand immune responses to human cancer and develop more effective immunotherapy, human tumor antigens has been isolated using various immunological methods with tumor reactive T cells or antibodies obtained from patients with melanoma. During the process of tumor antigen isolation, various molecules with genetic alterations or over-expression in tumor cells, which may be involved in proliferation, differentiation, or survival of various cancer cells, were identified. In melanoma, abnormal molecules with mutations including β -catenin, CDK4, and BRAF, and molecules with increased expression including Survivin, were immunologically detected. Therefore, immunological isolation of human tumor antigens contributes to the identification of important molecules including altered signaling molecules involved in melanoma formation.

元の言語English
ページ(範囲)357-366
ページ数10
ジャーナルCancer and Metastasis Reviews
24
発行部数2
DOI
出版物ステータスPublished - 2005 6

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Melanoma
Neoplasm Antigens
Neoplasms
Catenins
Immunotherapy
T-Lymphocytes
Mutation
Survival
Antibodies

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

これを引用

Immunological detection of altered signaling molecules involved in melanoma development. / Kawakami, Yutaka; Sumimoto, Hidetoshi; Fujita, Tomonobu; Matsuzaki, Yuriko.

:: Cancer and Metastasis Reviews, 巻 24, 番号 2, 06.2005, p. 357-366.

研究成果: Article

Kawakami, Yutaka ; Sumimoto, Hidetoshi ; Fujita, Tomonobu ; Matsuzaki, Yuriko. / Immunological detection of altered signaling molecules involved in melanoma development. :: Cancer and Metastasis Reviews. 2005 ; 巻 24, 番号 2. pp. 357-366.
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