## 抄録

The first component of complement {Mathematical expression} has been shown to degrade type I and type II collagens (Yamaguchi et al. 1990), the latter of which is a major constituent of the cartilage matrix. In order to understand the physiological roles of {Mathematical expression} in cartilage resorption, the expression of C1s was examined by immunohistochemistry in the primary ossification center where the matrix is removed and replaced by bone marrow. Hypertrophic chondrocytes, endothelium and hematogenous elements in the capillary buds were intensely stained by a monoclonal antibody against C1s. Matrix metalloproteinase 9 (MMP-9, 92kDa gelatinase/type IV collagenase) was also immunolocalized in hypertrophic chondrocytes, mesenchymal cells in the primitive bone marrow and the cartilage matrix adjacent to the marrow. In addition, {Mathematical expression} was found to activate the zymogen of MMP-9. These observations suggest that {Mathematical expression} and MMP-9 coordinately participate in matrix degradation in cartilage.

本文言語 | English |
---|---|

ページ（範囲） | 239-245 |

ページ数 | 7 |

ジャーナル | Cell & Tissue Research |

巻 | 277 |

号 | 2 |

DOI | |

出版ステータス | Published - 1994 8月 |

外部発表 | はい |

## ASJC Scopus subject areas

- 病理学および法医学
- 組織学
- 細胞生物学