Immunoregulation by the gut microbiota

Junko Nishio, Kenya Honda

研究成果: Review article査読

47 被引用数 (Scopus)

抄録

The human intestinal mucosa is constantly exposed to commensal microbiota. Since the gut microbiota is beneficial to the host, hosts have evolved intestinespecific immune systems to co-exist with the microbiota. On the other hand, the intestinal microbiota actively regulates the host's immune system, and recent studies have revealed that specific commensal bacterial species induce the accumulation of specific immune cell populations. For instance, segmented filamentous bacteria and Clostridium species belonging to clusters XIVa and IV induce the accumulation of Th17 cells in the small intestine and Foxp3? regulatory T cells in the large intestine, respectively. The immune cells induced by the gut microbiota likely contribute to intestinal homeostasis and influence systemic immunity in the host.

本文言語English
ページ(範囲)3635-3650
ページ数16
ジャーナルCellular and Molecular Life Sciences
69
21
DOI
出版ステータスPublished - 2012 11
外部発表はい

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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