Immunostimulating activity of celosian, an antihepatotoxic polysaccharide isolated from Celosia argentea

Koji Hase, Purusotam Basnet, Shigetoshi Kadota, Tsuneo Namba

研究成果: Article査読

37 被引用数 (Scopus)

抄録

Celosian, an acidic polysaccharide from the seeds of Celosia argentea (Amaranthaceae) was found to be a potent antihepatotoxic agent for chemical and immunological liver injury models in animals. The immunomodulating action of celosian was studied to clarify the preventive mechanism of celosian on liver injuries. Celosian induced tumor necrosis factor-α (TNF-α) production in mice. Celosian also induced the production of interleukin-1β (IL-1β) and nitric oxide (NO) in macrophage cell line J774.1 in a concentration-dependent manner (1 to 1000/μg/ml). Moreover, celosian induced IL-1β secretion in human mononuclear cells. In addition, celosian enhanced gamma interferon (IFN-υ) production activity of concanavalin A (Con A) in mice spleen cells, though celosian alone did not significantly influence IFN-υ production. These results indicate that celosian is an immunostimulating agent in addition to antihepatotoxic effects.

本文言語English
ページ(範囲)216-219
ページ数4
ジャーナルPlanta Medica
63
3
DOI
出版ステータスPublished - 1997
外部発表はい

ASJC Scopus subject areas

  • 分析化学
  • 分子医療
  • 薬理学
  • 薬科学
  • 創薬
  • 補完代替医療
  • 有機化学

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