Immunotherapy using human melanoma epitopes recognized by T cells

Y. Kawakami

研究成果: Article査読

抄録

Tumor reactive T cells can be induced from peripheral blood or tumor infiltrating lymphocytes of patients with melanoma. Based on the analysis of the previous immunotherapies, T cells appeared to be involved in vivo tumor regression. Genes encoding human melanoma antigens and their epitope peptides recognized by T cells, have been identified using cDNA expression cloning techniques. Mechanisms for generation of T cell epitopes on growing melanoma cells have been identified. A variety of Phase I clinical studies using MART- 1 and gp100 antigens are being performed in the Surgery Branch, National Cancer Institute, NIH, and some patients have responded to these immunotherapy protocols.

本文言語English
ページ(範囲)542-548
ページ数7
ジャーナルBiotherapy
12
5
出版ステータスPublished - 1998 1月 1

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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