TY - JOUR
T1 - Impact of cataract on health-related quality of life in a longitudinal Japanese chronic obstructive pulmonary cohort
AU - On behalf of the Keio COPD Comorbidity Research (K-CCR) Group
AU - Irie, Hidehiro
AU - Chubachi, Shotaro
AU - Sato, Minako
AU - Sasaki, Mamoru
AU - Kameyama, Naofumi
AU - Inoue, Takashi
AU - Oyamada, Yoshitaka
AU - Nakamura, Hidetoshi
AU - Asano, Koichiro
AU - Betsuyaku, Tomoko
N1 - Funding Information:
The authors would like to thank Kazuo Tsubota of the Department of Ophthalmology, Keio University School of Medicine, for helping in the ophthalmologic examinations; Chiyomi Uemura for helping with data collection; and all the members of the Keio COPD Comorbidity Research group, who participated in this study, including Saiseikai Utsunomiya Hospital, Eiju General Hospital, Tokyo Saiseikai Central Hospital, Sano Public Welfare General Hospital, Nihon Kokan Hospital, Saitama Social Insurance Hospital, Kawasaki City Ida Hospital, Saitama City Hospital, Tokyo Medical Center, Tokyo Dental College Ichikawa General Hospital, Tokyo Electric Power Company Hospital, and the International Medical Welfare College Shioya Hospital. The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Cigarette smoking increases the risk of developing both cataract and chronic obstructive pulmonary disease (COPD). The prevalence of cataract and the clinical characteristics of COPD patients with cataract were retrospectively investigated in a 2-year observational COPD cohort. We analyzed 395 patients with complete data on ophthalmologic evaluation (319 subjects with COPD and 76 subjects at risk of COPD). There was no difference in the prevalence of cataract between COPD patients and those at risk (47.0% vs. 42.1%, p = 0.44). Age ≥ 75 years, low body mass index, and hypertension were independently associated with cataract as a comorbidity in COPD. The incidence of exacerbation within 2 years was significantly higher in COPD patients with cataract than those without cataract (36.6% vs. 18.3%, p = 0.0019). COPD patients with cataract exhibited significantly higher COPD assessment test score compared to those without cataract (13.7 ± 8.9 vs. 11.5 ± 7.2, p = 0.0240). Overall St George’s Respiratory Questionnaire score and each component were significantly worse in COPD patients with cataract compared to those without cataract. COPD patients with cataract exhibited poor health-related quality of life and frequent exacerbations. The association between cataract and exacerbations of COPD deserves further attention.
AB - Cigarette smoking increases the risk of developing both cataract and chronic obstructive pulmonary disease (COPD). The prevalence of cataract and the clinical characteristics of COPD patients with cataract were retrospectively investigated in a 2-year observational COPD cohort. We analyzed 395 patients with complete data on ophthalmologic evaluation (319 subjects with COPD and 76 subjects at risk of COPD). There was no difference in the prevalence of cataract between COPD patients and those at risk (47.0% vs. 42.1%, p = 0.44). Age ≥ 75 years, low body mass index, and hypertension were independently associated with cataract as a comorbidity in COPD. The incidence of exacerbation within 2 years was significantly higher in COPD patients with cataract than those without cataract (36.6% vs. 18.3%, p = 0.0019). COPD patients with cataract exhibited significantly higher COPD assessment test score compared to those without cataract (13.7 ± 8.9 vs. 11.5 ± 7.2, p = 0.0240). Overall St George’s Respiratory Questionnaire score and each component were significantly worse in COPD patients with cataract compared to those without cataract. COPD patients with cataract exhibited poor health-related quality of life and frequent exacerbations. The association between cataract and exacerbations of COPD deserves further attention.
KW - COPD assessment test
KW - Chronic obstructive pulmonary disease
KW - cataract
KW - exacerbation
KW - quality of life
UR - http://www.scopus.com/inward/record.url?scp=85050859830&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85050859830&partnerID=8YFLogxK
U2 - 10.1177/1479972317745735
DO - 10.1177/1479972317745735
M3 - Article
C2 - 29232989
AN - SCOPUS:85050859830
VL - 15
SP - 329
EP - 338
JO - Chronic Respiratory Disease
JF - Chronic Respiratory Disease
SN - 1479-9723
IS - 4
ER -