Impact of Chronic Kidney Disease on Postinfarction Inflammation, Oxidative Stress, and Left Ventricular Remodeling

Kotaro Naito, Toshihisa Anzai, Tsutomu Yoshikawa, Atsushi Anzai, Hidehiro Kaneko, Takashi Kohno, Toshiyuki Takahashi, Akio Kawamura, Satoshi Ogawa

研究成果: Article

18 引用 (Scopus)

抄録

Background: Patients with chronic kidney disease (CKD) have poor clinical outcomes after myocardial infarction (MI). However, the precise mechanisms are unclear. We sought to determine the prognostic significance of CKD in patients with MI in relation to left ventricular (LV) remodeling. Methods and Results: We examined 120 consecutive patients with a reperfused first anterior ST-elevation MI. Patients were divided into 2 groups according to the presence or absence of CKD, defined as estimated glomerular filtration rates <60 mL·min·1.73 m2. Patients with CKD had a higher incidence of in-hospital cardiac death and readmission for heart failure during follow-up, in association with a greater LV volume and lower LV ejection fraction 2 weeks after MI compared with those without CKD. Cox proportional hazards model analysis revealed that CKD was an independent predictor of major adverse cardiac events (hazard ratio = 3.13, P = .001). Plasma interleukin-6 on admission, and peak serum C-reactive protein, and malondialdehyde-modified low-density lipoprotein levels during convalescence, were higher in patients with CKD than in those without. Conclusions: Patients with CKD had poorer clinical outcomes and accelerated infarct expansion in association with enhanced inflammation and oxidative stress, as compared with non-CKD patients, suggesting a major impact of CKD in the development of LV remodeling after MI.

元の言語English
ページ(範囲)831-838
ページ数8
ジャーナルJournal of Cardiac Failure
14
発行部数10
DOI
出版物ステータスPublished - 2008 12

Fingerprint

Ventricular Remodeling
Chronic Renal Insufficiency
Oxidative Stress
Inflammation
Myocardial Infarction
Kidney Diseases
Malondialdehyde
Glomerular Filtration Rate
LDL Lipoproteins
Proportional Hazards Models
Stroke Volume
C-Reactive Protein
Blood Proteins
Interleukin-6
Heart Failure
Incidence

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

これを引用

Impact of Chronic Kidney Disease on Postinfarction Inflammation, Oxidative Stress, and Left Ventricular Remodeling. / Naito, Kotaro; Anzai, Toshihisa; Yoshikawa, Tsutomu; Anzai, Atsushi; Kaneko, Hidehiro; Kohno, Takashi; Takahashi, Toshiyuki; Kawamura, Akio; Ogawa, Satoshi.

:: Journal of Cardiac Failure, 巻 14, 番号 10, 12.2008, p. 831-838.

研究成果: Article

Naito, K, Anzai, T, Yoshikawa, T, Anzai, A, Kaneko, H, Kohno, T, Takahashi, T, Kawamura, A & Ogawa, S 2008, 'Impact of Chronic Kidney Disease on Postinfarction Inflammation, Oxidative Stress, and Left Ventricular Remodeling', Journal of Cardiac Failure, 巻. 14, 番号 10, pp. 831-838. https://doi.org/10.1016/j.cardfail.2008.07.233
Naito, Kotaro ; Anzai, Toshihisa ; Yoshikawa, Tsutomu ; Anzai, Atsushi ; Kaneko, Hidehiro ; Kohno, Takashi ; Takahashi, Toshiyuki ; Kawamura, Akio ; Ogawa, Satoshi. / Impact of Chronic Kidney Disease on Postinfarction Inflammation, Oxidative Stress, and Left Ventricular Remodeling. :: Journal of Cardiac Failure. 2008 ; 巻 14, 番号 10. pp. 831-838.
@article{9cf58e3706a44faa90a22178a4adf589,
title = "Impact of Chronic Kidney Disease on Postinfarction Inflammation, Oxidative Stress, and Left Ventricular Remodeling",
abstract = "Background: Patients with chronic kidney disease (CKD) have poor clinical outcomes after myocardial infarction (MI). However, the precise mechanisms are unclear. We sought to determine the prognostic significance of CKD in patients with MI in relation to left ventricular (LV) remodeling. Methods and Results: We examined 120 consecutive patients with a reperfused first anterior ST-elevation MI. Patients were divided into 2 groups according to the presence or absence of CKD, defined as estimated glomerular filtration rates <60 mL·min·1.73 m2. Patients with CKD had a higher incidence of in-hospital cardiac death and readmission for heart failure during follow-up, in association with a greater LV volume and lower LV ejection fraction 2 weeks after MI compared with those without CKD. Cox proportional hazards model analysis revealed that CKD was an independent predictor of major adverse cardiac events (hazard ratio = 3.13, P = .001). Plasma interleukin-6 on admission, and peak serum C-reactive protein, and malondialdehyde-modified low-density lipoprotein levels during convalescence, were higher in patients with CKD than in those without. Conclusions: Patients with CKD had poorer clinical outcomes and accelerated infarct expansion in association with enhanced inflammation and oxidative stress, as compared with non-CKD patients, suggesting a major impact of CKD in the development of LV remodeling after MI.",
keywords = "Acute myocardial infarction, chronic kidney disease, inflammation, oxidative stress",
author = "Kotaro Naito and Toshihisa Anzai and Tsutomu Yoshikawa and Atsushi Anzai and Hidehiro Kaneko and Takashi Kohno and Toshiyuki Takahashi and Akio Kawamura and Satoshi Ogawa",
year = "2008",
month = "12",
doi = "10.1016/j.cardfail.2008.07.233",
language = "English",
volume = "14",
pages = "831--838",
journal = "Journal of Cardiac Failure",
issn = "1071-9164",
publisher = "Churchill Livingstone",
number = "10",

}

TY - JOUR

T1 - Impact of Chronic Kidney Disease on Postinfarction Inflammation, Oxidative Stress, and Left Ventricular Remodeling

AU - Naito, Kotaro

AU - Anzai, Toshihisa

AU - Yoshikawa, Tsutomu

AU - Anzai, Atsushi

AU - Kaneko, Hidehiro

AU - Kohno, Takashi

AU - Takahashi, Toshiyuki

AU - Kawamura, Akio

AU - Ogawa, Satoshi

PY - 2008/12

Y1 - 2008/12

N2 - Background: Patients with chronic kidney disease (CKD) have poor clinical outcomes after myocardial infarction (MI). However, the precise mechanisms are unclear. We sought to determine the prognostic significance of CKD in patients with MI in relation to left ventricular (LV) remodeling. Methods and Results: We examined 120 consecutive patients with a reperfused first anterior ST-elevation MI. Patients were divided into 2 groups according to the presence or absence of CKD, defined as estimated glomerular filtration rates <60 mL·min·1.73 m2. Patients with CKD had a higher incidence of in-hospital cardiac death and readmission for heart failure during follow-up, in association with a greater LV volume and lower LV ejection fraction 2 weeks after MI compared with those without CKD. Cox proportional hazards model analysis revealed that CKD was an independent predictor of major adverse cardiac events (hazard ratio = 3.13, P = .001). Plasma interleukin-6 on admission, and peak serum C-reactive protein, and malondialdehyde-modified low-density lipoprotein levels during convalescence, were higher in patients with CKD than in those without. Conclusions: Patients with CKD had poorer clinical outcomes and accelerated infarct expansion in association with enhanced inflammation and oxidative stress, as compared with non-CKD patients, suggesting a major impact of CKD in the development of LV remodeling after MI.

AB - Background: Patients with chronic kidney disease (CKD) have poor clinical outcomes after myocardial infarction (MI). However, the precise mechanisms are unclear. We sought to determine the prognostic significance of CKD in patients with MI in relation to left ventricular (LV) remodeling. Methods and Results: We examined 120 consecutive patients with a reperfused first anterior ST-elevation MI. Patients were divided into 2 groups according to the presence or absence of CKD, defined as estimated glomerular filtration rates <60 mL·min·1.73 m2. Patients with CKD had a higher incidence of in-hospital cardiac death and readmission for heart failure during follow-up, in association with a greater LV volume and lower LV ejection fraction 2 weeks after MI compared with those without CKD. Cox proportional hazards model analysis revealed that CKD was an independent predictor of major adverse cardiac events (hazard ratio = 3.13, P = .001). Plasma interleukin-6 on admission, and peak serum C-reactive protein, and malondialdehyde-modified low-density lipoprotein levels during convalescence, were higher in patients with CKD than in those without. Conclusions: Patients with CKD had poorer clinical outcomes and accelerated infarct expansion in association with enhanced inflammation and oxidative stress, as compared with non-CKD patients, suggesting a major impact of CKD in the development of LV remodeling after MI.

KW - Acute myocardial infarction

KW - chronic kidney disease

KW - inflammation

KW - oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=56449086727&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=56449086727&partnerID=8YFLogxK

U2 - 10.1016/j.cardfail.2008.07.233

DO - 10.1016/j.cardfail.2008.07.233

M3 - Article

C2 - 19041046

AN - SCOPUS:56449086727

VL - 14

SP - 831

EP - 838

JO - Journal of Cardiac Failure

JF - Journal of Cardiac Failure

SN - 1071-9164

IS - 10

ER -