Impact of postoperative complications on the colorectal cancer survival and recurrence: analyses of pooled individual patients’ data from three large phase III randomized trials

Toru Aoyama, Koji Oba, Michitaka Honda, Sotaro Sadahiro, Chikuma Hamada, Shuhei Mayanagi, Mitsuro Kanda, Hiromichi Maeda, Kosuke Kashiwabara, Junichi Sakamoto, Shigetoyo Saji, Takaki Yoshikawa

研究成果: Article

22 引用 (Scopus)

抜粋

This study assessed the impact of postoperative complications on the colorectal cancer survival and recurrence after curative surgery using pooled individual patients’ data from three large phase III randomized trials. In total, 5530 patients were included in this study. The patients were classified as those with postoperative complications (C group) and those without postoperative complications (NC group). The risk factors for the overall survival (OS) and the disease-free survival (DFS) were analyzed. Postoperative complications were found in 861 (15.6%) of the 5530 patients. The OS and DFS rates at 5 years after surgery were 68.9% and 74.8%, respectively, in the C group and 75.8% and 82.2%, respectively, in the NC group, values that were significantly different between the two groups (P < 0.001). The multivariate analysis demonstrated that postoperative complications were a significant independent risk factor for the OS and DFS. Postoperative complications can worsen the colorectal cancer survival and risk of recurrence. Surgical morbidity must be considered as a stratification factor in future phase III trials evaluating the effects of adjuvant chemotherapy on colorectal cancer.

元の言語English
ページ(範囲)1573-1580
ページ数8
ジャーナルCancer medicine
6
発行部数7
DOI
出版物ステータスPublished - 2017 7

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

フィンガープリント Impact of postoperative complications on the colorectal cancer survival and recurrence: analyses of pooled individual patients’ data from three large phase III randomized trials' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Aoyama, T., Oba, K., Honda, M., Sadahiro, S., Hamada, C., Mayanagi, S., Kanda, M., Maeda, H., Kashiwabara, K., Sakamoto, J., Saji, S., & Yoshikawa, T. (2017). Impact of postoperative complications on the colorectal cancer survival and recurrence: analyses of pooled individual patients’ data from three large phase III randomized trials. Cancer medicine, 6(7), 1573-1580. https://doi.org/10.1002/cam4.1126