Impact of pretransplant body mass index on the clinical outcome after allogeneic hematopoietic SCT

S. Fuji, K. Takano, T. Mori, T. Eto, S. Taniguchi, K. Ohashi, H. Sakamaki, Y. Morishima, K. Kato, K. Miyamura, R. Suzuki, T. Fukuda

研究成果: Article

35 引用 (Scopus)

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To elucidate the impact of pretransplant body mass index (BMI) on the clinical outcome, we performed a retrospective study with registry data including a total of 12 050 patients (age ≥18 years) who received allogeneic hematopoietic SCT (HSCT) between 2000 and 2010. Patients were stratified as follows: BMI<18.5 kg/m 2, Underweight, n=1791; 18.5≤BMI<25, Normal, n=8444; 25≤BMI<30, Overweight, n=1591; BMI≥30, Obese, n=224. The median age was 45 years (range, 18-77). A multivariate analysis showed that the risk of relapse was significantly higher in the underweight group and lower in the overweight and obese groups compared with the normal group (hazard ratio (HR), 1.16, 0.86, and 0.74, respectively). The risk of GVHD was significantly higher in the overweight group compared with the normal group. The risk of non-relapse mortality (NRM) was significantly higher in the overweight and obese group compared with the normal group (HR 1.19 and HR 1.43, respectively). The probability of OS was lower in the underweight group compared with the normal group (HR 1.10, P=0.018). In conclusion, pretransplant BMI affected the risk of relapse and NRM after allogeneic HSCT. Underweight was a risk factor for poor OS because of an increased risk of relapse. Obesity was a risk factor for NRM.

元の言語English
ページ(範囲)1505-1512
ページ数8
ジャーナルBone Marrow Transplantation
49
発行部数12
DOI
出版物ステータスPublished - 2014 12 11

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ASJC Scopus subject areas

  • Hematology
  • Transplantation

これを引用

Fuji, S., Takano, K., Mori, T., Eto, T., Taniguchi, S., Ohashi, K., Sakamaki, H., Morishima, Y., Kato, K., Miyamura, K., Suzuki, R., & Fukuda, T. (2014). Impact of pretransplant body mass index on the clinical outcome after allogeneic hematopoietic SCT. Bone Marrow Transplantation, 49(12), 1505-1512. https://doi.org/10.1038/bmt.2014.178