Impaired bone fracture healing in matrix metalloproteinase-13 deficient mice

Naoto Kosaki, Hironari Takaishi, Satoru Kamekura, Tokuhiro Kimura, Yasunori Okada, Li Minqi, Norio Amizuka, Ung il Chung, Kozo Nakamura, Hiroshi Kawaguchi, Yoshiaki Toyama, Jeanine D'Armiento

研究成果: Article査読

87 被引用数 (Scopus)


Vascular and cellular invasion into the cartilage is a critical step in the fracture healing. Matrix metalloproteinase-13 (MMP-13) is a member of the zinc-dependent endopeptidase family and plays an important role in remodeling of extracellular matrix. Therefore we investigated the possible involvement of MMP-13 in a murine model of stabilized bone fracture healing. Repair of the fracture in MMP-13 deficient (MMP-13-/-) mice was significantly delayed and characterized by a retarded cartilage resorption in the fracture callus. Immunohistochemistry indicated severe defects in vascular penetration and chondroclast recruitment to the fracture callus in MMP-13-/- mice. Consistent with the observations, the chondrocyte pellets cultured from the MMP13-/- mice exhibited diminished angiogenic activities when the pellets were co-cultured with endothelial cells. These results suggest that MMP-13 is crucial to the process of angiogenesis during healing of fracture, especially in the cartilage resorption process.

ジャーナルBiochemical and Biophysical Research Communications
出版ステータスPublished - 2007 3 23

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学


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