Impaired myogenic responsiveness of the afferent arteriole in streptozotocin-induced diabetic rats: Role of eicosanoid derangements

Koichi Hayashi, Murray Epstein, Rodger Loutzenhiser, Haytey Forster

研究成果: Article査読

122 被引用数 (Scopus)

抄録

Evidence suggests that diabetes is associated with an impairment of renal autoregulation. It has previously been demonstrated that pressure-induced (myogenic) afferent arteriolar vasoconstriction is well preserved in the isolated perfused hydronephrotic kidney. In this study, pressure-induced afferent arteriolar vasoconstriction was examined in kidneys from sfreptozotocin-induced diabetic rats. Vessel diameters were measured by videomicroscopy as renal arterial pressure was elevated from 80 to 180 mm Hg. In normal kidneys, the afferent arteriole vasoconstricted progressively as renal arterial pressure was increased (-24 ± 2% decrement in diameter at 180 mm Hg; N = 35; P < 0.001). In contrast, afferent arterioles of diabetic kidneys exhibited a greatly attenuated response to pressure (i.e., -3 ± 2% change at 180 mm Hg; N = 60). In vitro treatment wilh 100 μM ibuprofen completely restored myogenic vasoconstriction (-21 ± 2% change at 180 mm Hg), but did not alter myogenic responses of control (i.e., nondiabetic) kidneys. The control of hyperglycemie by insulin treatment resulted in a partial preservation of myogenic vasoconstriction (i.e., -11 ± 3% change at 180 mm Hg), which was further restored by the administration of a low dose (10 μM) of ibuprofen (-21 ± 1% change at 180 mm Hg). These observations indicate that diabetes is associated with an impaired responsiveness of the afferent arteriole to pressure that is mediated by an alteration in eicosanoid metabolism. This deranged renal microcirculatory response to pressure may represent a functional impairment of the diabetic kidney that may contribute to the progression of diabetic nephropathy.

本文言語English
ページ(範囲)1578-1586
ページ数9
ジャーナルJournal of the American Society of Nephrology
2
11
出版ステータスPublished - 1992 5月 1

ASJC Scopus subject areas

  • 腎臓病学

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