Implication of cyclooxygenase-2 on enhanced proliferation of neural progenitor cells in the adult mouse hippocampus after ischemia

Tsutomu Sasaki, Kazuo Kitagawa, Shiro Sugiura, Emi Omura-Matsuoka, Shigeru Tanaka, Yoshiki Yagita, Hideyuki Okano, Masayasu Matsumoto, Masatsugu Hori

研究成果: Article査読

83 被引用数 (Scopus)

抄録

Global ischemia promotes neurogenesis in the dentate gyrus of the adult mouse hippocampus. Cyclooxygenase (COX)-2, the principal isoenzyme in the brain, modulates inflammation, glutamate-mediated cytotoxicity, and synaptic plasticity. We demonstrated that delayed treatment with different classes of COX inhibitor significantly blunted enhancement of dentate gyrus proliferation of neural progenitor cells after ischemia. COX-2 immunore-activity was observed in both neurons and astrocytes in the dentate gyrus, but not in neural progenitor cells in the subgranular zone. Moreover, in the postischemic dentate gyrus of heterozygous and homozygous COX-2 knock-out mice, proliferating bromodeoxyuridine-positive cells were significantly fewer than in wild-type littermates. These results demonstrate that COX-2 is an important modulator in enhancement of proliferation of neural progenitor cells after ischemia.

本文言語English
ページ(範囲)461-471
ページ数11
ジャーナルJournal of neuroscience research
72
4
DOI
出版ステータスPublished - 2003 5月 15

ASJC Scopus subject areas

  • 細胞および分子神経科学

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