In vitro activity of tebipenem, a new oral carbapenem antibiotic, against β-lactamase-nonproducing, ampicillin-resistant Haemophilus influenzae

Kozue Kishii, Naoko Chiba, Miyuki Morozumi, Akiko Ono, Takashi Ida, Kimiko Ubukata

研究成果: Article査読

8 被引用数 (Scopus)

抄録

In vitro activity of tebipenem, a new oral carbapenem antibiotic, against clinical Haemophilus influenzae isolates was compared with those of 8 reference agents. Isolates were classified into 6 resistance classes after PCR identification of β-lactamase genes and ftsI gene mutations. For all isolates, the minimal concentration at which 90% of isolates were inhibited was lower for tebipenem than for the reference oral antibiotics, except for cefditoren. Tebipenem also showed excellent bactericidal activity against β-lactamase-nonproducing, ampicillin-resistant isolates.

本文言語English
ページ(範囲)3970-3973
ページ数4
ジャーナルAntimicrobial Agents and Chemotherapy
54
9
DOI
出版ステータスPublished - 2010 9

ASJC Scopus subject areas

  • 薬理学
  • 薬理学(医学)
  • 感染症

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