In vitro and in vivo tests of nanoporous membrane coated with biocompatible fluorine-doped diamond-like carbon for hemofiltration treatment

Takashi Ota, Masamitsu Nakayama, Yoshihiko Kanno, Tetsuya Suzuki, Norihisa Miki

研究成果: Conference contribution

1 引用 (Scopus)

抜粋

In this report, we experimentally investigated the blood hemofiltration capacity of a nanoporous dialysis membrane (poly(ether sulfone), PES) whose surface was modified with fluorine-doped diamond-like carbon(f-DLC). Surface modification of the nanoporous membrane without clogging the nanopores is challenging. In vitro experiments revealed that the modified membrane successfully exhibited water permeability of one-tenth of the untreated. In vivo experiments with ultra-small hemofiltration devices composed of f-DLC PES membranes using SD rats were also conducted for the first time. The results proved that the f-DLC coated PES membrane can be used for hemofiltration, which will extend the lifetime of microfluidics-based implantable artificial kidney.

元の言語English
ホスト出版物のタイトル2018 IEEE Micro Electro Mechanical Systems, MEMS 2018
出版者Institute of Electrical and Electronics Engineers Inc.
ページ412-414
ページ数3
2018-January
ISBN(電子版)9781538647820
DOI
出版物ステータスPublished - 2018 4 24
イベント31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018 - Belfast, United Kingdom
継続期間: 2018 1 212018 1 25

Other

Other31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018
United Kingdom
Belfast
期間18/1/2118/1/25

    フィンガープリント

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Mechanical Engineering
  • Electrical and Electronic Engineering

これを引用

Ota, T., Nakayama, M., Kanno, Y., Suzuki, T., & Miki, N. (2018). In vitro and in vivo tests of nanoporous membrane coated with biocompatible fluorine-doped diamond-like carbon for hemofiltration treatment. : 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018 (巻 2018-January, pp. 412-414). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MEMSYS.2018.8346575