In vitro combination effect of glycopeptides and β-lactams against methicillin-resistant Staphylococcus aureus

Yoshitake Sato, Mitsuru Sando, Satoshi Iwata, Hironobu Akita, Keisuke Sunakawa

研究成果: Article

抜粋

We investigated the combination effect of teicoplanin (TEIC) or vancomycin (VCM) and 6 β-lactams in vitro using 49 strains of methicillin-resistant Staphylococcus aureus (MRSA) isolated from neonates who were admitted to the newborn intensive care unit. We combined TEIC with imipenem (IPM), meropenem (MEPM), panipenem (PAPM), cefpirome (CPR), flomoxef (FMOX), or sulbactam (SBT)/ampicillin (ABPC). Synergistic effects were noted in 16 to 48 strains. In particular, the combinations of TEIC and IPM, MEPM, PAPM, or FMOX showed synergistic effects in many strains. Furthermore, 3 strains did not respond to the combination of TEIC and CPR; however, none of the strains exhibited antagonism. Combination with VCM and the above β-lactams produced synergistic effects in 1 to 32 strains. No changes were seen in 1 to 17 strains, and 2 to 6 strains exhibited antagonism. These results suggest that, when combined with the β-lactams tested, TEIC exhibits more potent synergistic effects than VCM.

元の言語English
ページ(範囲)95-101
ページ数7
ジャーナルJapanese Journal of Chemotherapy
54
発行部数2
出版物ステータスPublished - 2006 2 1

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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