In Vitro Osteogenic Activity of Rat Bone Marrow Derived Mesenchymal Stem Cells Cultured on Transparent Hydroxyapatite Ceramics

Noriko Kotobuki, Daisuke Kawagoe, Hirotaka Fujimori, Seishi Goto, Koji Loku, Hajime Ohgushi

研究成果: Conference article査読

10 被引用数 (Scopus)

抄録

Direct observation of cultured cells on various materials has benefit for assessment of fundamental cellular functions including cell attachment, spreading, proliferation and differentiation on the materials. For this purpose, we made transparent hydroxyapatite (tHA) ceramics, where cultured rat bone marrow-derived mesenchymal stem cells (rMSCs) could be visible by phase contrast microscopy immediately after plating. The seeded rMSCs adhered and proliferated on the tHA ceramics. Furtheremore, the cells cultured on the tHA ceramics were able to differentiate into osteoblasts under osteogenic conditions and showed comparable osteogenic activity to the cells cultured on tissue culture polystyrene dishes. The results suggested that cultured cells could be monitored in a time dependent manner using the tHA ceramics.

本文言語English
ページ(範囲)1055-1058
ページ数4
ジャーナルKey Engineering Materials
254-256
出版ステータスPublished - 2004 1 1
外部発表はい
イベントThe Annual Meeting of the International Society for Ceramics in Medicine - Porto, Portugal
継続期間: 2003 11 62003 11 9

ASJC Scopus subject areas

  • 材料科学(全般)
  • 材料力学
  • 機械工学

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