In vitro protein binding of teicoplanin to neonatal serum

Mitsuru Sando, Yoshitake Sato, Satoshi Iwata, Hironobu Akita, Keisuke Sunakawa

研究成果: Article査読

2 被引用数 (Scopus)

抄録

The protein-binding ability of teicoplanin (TEIC) to neonatal serum was investigated and the following results were obtained. (1) The protein binding ability of TEIC at concentrations ranging from 10 to 100 μg/ml, to neonatal serum was 80.5%-71.9% and was generally low as compared with that for adult serum. (2) The protein binding ability of TEIC (20 μg/ml) to albumin in neonatal serum was not concentration-dependent, and the correlation between the protein-binding ability and albumin concentration was low. Namely, it was suggested that the protein-binding ability of TEIC to neonatal serum was not dependent merely on the albumin concentration, and there was a possibility that the protein-binding ability also depended on qualitative changes in albumin. (3) The protein-binding ability of TEIC (20 μg/ml) to total bilirubin and free bilirubin was not concentration-dependent, and the correlation was extremely low, indicating that there is a low possibility that the protein-binding ability of TEIC induces an increase in free bilirubin.

本文言語English
ページ(範囲)280-283
ページ数4
ジャーナルJournal of Infection and Chemotherapy
10
5
DOI
出版ステータスPublished - 2004 10

ASJC Scopus subject areas

  • 微生物学(医療)
  • 薬理学(医学)
  • 感染症

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