In vivo confocal microscopy evaluation of meibomian gland dysfunction in atopic-keratoconjunctivitis patients

Osama M A Ibrahim, Yukihiro Matsumoto, Murat Dogru, Enrique Sato Adan, Tais Hitomi Wakamatsu, Jun Shimazaki, Hiroshi Fujishima, Kazuo Tsubota

研究成果: Article

30 引用 (Scopus)

抄録

Purpose: To clarify meibomian gland (MG) alterations in atopic keratoconjunctivitis (AKC) patients and compare the findings with obstructive MG dysfunction (MGD) patients and control subjects using in vivo confocal microscopy (CM). Design: Prospective, controlled, single-center study. Participants: Twelve AKC patients (10 males, 2 females; mean age, 31.0±16.5 years), 12 obstructive MGD patients (7 males, 5 females; mean age, 37.6±5.6 years), and 26 control subjects (13 males, 13 females; mean age, 32.9±5.7 years) were recruited. No significant age or gender differences were observed between the 3 groups. Methods: All subjects underwent assessment of tear evaporation rate from the ocular surface (TEROS), slit-lamp examinations, tear break-up time (BUT) measurements, vital staining, Schirmer test I, meibography, MG expressibility, and CM examination of the MG (HRTII-RCM). Statistical analysis was performed using the Mann-Whitney test. Main Outcome Measures: The MG acinar unit density, inflammatory cell density, MG acinar unit longest diameter, MG acinar unit shortest diameter, and MG acinar unit area as observed by in vivo CM, MG drop-out, MG expressibility grading, tear stability, tear evaporation, and vital staining scores. Results: The TEROS values, mean BUT, vital staining scores, MG expressibility, and MG dropout grades were significantly worse in AKC patients compared with those in obstructive MGD patients and controls (P<0.05). The mean values of the CM parameters in AKC patients were significantly worse than those observed in the obstructive MGD patients and controls (P<0.001). Conclusions: Changes in MG in AKC patients seem to be more severe than in patients with obstructive MGD and controls. In vivo CM is a noninvasive, efficient tool in the assessment of MG status and ocular surface disease in AKC. Financial Disclosure(s): The authors have no proprietary or commercial interest in any of the materials discussed in this article.

元の言語English
ページ(範囲)1961-1968
ページ数8
ジャーナルOphthalmology
119
発行部数10
DOI
出版物ステータスPublished - 2012 10

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Meibomian Glands
Keratoconjunctivitis
Confocal Microscopy
Tears
Staining and Labeling
Intravital Microscopy
Eye Diseases
Disclosure

ASJC Scopus subject areas

  • Ophthalmology

これを引用

Ibrahim, O. M. A., Matsumoto, Y., Dogru, M., Adan, E. S., Wakamatsu, T. H., Shimazaki, J., ... Tsubota, K. (2012). In vivo confocal microscopy evaluation of meibomian gland dysfunction in atopic-keratoconjunctivitis patients. Ophthalmology, 119(10), 1961-1968. https://doi.org/10.1016/j.ophtha.2012.04.001

In vivo confocal microscopy evaluation of meibomian gland dysfunction in atopic-keratoconjunctivitis patients. / Ibrahim, Osama M A; Matsumoto, Yukihiro; Dogru, Murat; Adan, Enrique Sato; Wakamatsu, Tais Hitomi; Shimazaki, Jun; Fujishima, Hiroshi; Tsubota, Kazuo.

:: Ophthalmology, 巻 119, 番号 10, 10.2012, p. 1961-1968.

研究成果: Article

Ibrahim, OMA, Matsumoto, Y, Dogru, M, Adan, ES, Wakamatsu, TH, Shimazaki, J, Fujishima, H & Tsubota, K 2012, 'In vivo confocal microscopy evaluation of meibomian gland dysfunction in atopic-keratoconjunctivitis patients', Ophthalmology, 巻. 119, 番号 10, pp. 1961-1968. https://doi.org/10.1016/j.ophtha.2012.04.001
Ibrahim OMA, Matsumoto Y, Dogru M, Adan ES, Wakamatsu TH, Shimazaki J その他. In vivo confocal microscopy evaluation of meibomian gland dysfunction in atopic-keratoconjunctivitis patients. Ophthalmology. 2012 10;119(10):1961-1968. https://doi.org/10.1016/j.ophtha.2012.04.001
Ibrahim, Osama M A ; Matsumoto, Yukihiro ; Dogru, Murat ; Adan, Enrique Sato ; Wakamatsu, Tais Hitomi ; Shimazaki, Jun ; Fujishima, Hiroshi ; Tsubota, Kazuo. / In vivo confocal microscopy evaluation of meibomian gland dysfunction in atopic-keratoconjunctivitis patients. :: Ophthalmology. 2012 ; 巻 119, 番号 10. pp. 1961-1968.
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abstract = "Purpose: To clarify meibomian gland (MG) alterations in atopic keratoconjunctivitis (AKC) patients and compare the findings with obstructive MG dysfunction (MGD) patients and control subjects using in vivo confocal microscopy (CM). Design: Prospective, controlled, single-center study. Participants: Twelve AKC patients (10 males, 2 females; mean age, 31.0±16.5 years), 12 obstructive MGD patients (7 males, 5 females; mean age, 37.6±5.6 years), and 26 control subjects (13 males, 13 females; mean age, 32.9±5.7 years) were recruited. No significant age or gender differences were observed between the 3 groups. Methods: All subjects underwent assessment of tear evaporation rate from the ocular surface (TEROS), slit-lamp examinations, tear break-up time (BUT) measurements, vital staining, Schirmer test I, meibography, MG expressibility, and CM examination of the MG (HRTII-RCM). Statistical analysis was performed using the Mann-Whitney test. Main Outcome Measures: The MG acinar unit density, inflammatory cell density, MG acinar unit longest diameter, MG acinar unit shortest diameter, and MG acinar unit area as observed by in vivo CM, MG drop-out, MG expressibility grading, tear stability, tear evaporation, and vital staining scores. Results: The TEROS values, mean BUT, vital staining scores, MG expressibility, and MG dropout grades were significantly worse in AKC patients compared with those in obstructive MGD patients and controls (P<0.05). The mean values of the CM parameters in AKC patients were significantly worse than those observed in the obstructive MGD patients and controls (P<0.001). Conclusions: Changes in MG in AKC patients seem to be more severe than in patients with obstructive MGD and controls. In vivo CM is a noninvasive, efficient tool in the assessment of MG status and ocular surface disease in AKC. Financial Disclosure(s): The authors have no proprietary or commercial interest in any of the materials discussed in this article.",
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T1 - In vivo confocal microscopy evaluation of meibomian gland dysfunction in atopic-keratoconjunctivitis patients

AU - Ibrahim, Osama M A

AU - Matsumoto, Yukihiro

AU - Dogru, Murat

AU - Adan, Enrique Sato

AU - Wakamatsu, Tais Hitomi

AU - Shimazaki, Jun

AU - Fujishima, Hiroshi

AU - Tsubota, Kazuo

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N2 - Purpose: To clarify meibomian gland (MG) alterations in atopic keratoconjunctivitis (AKC) patients and compare the findings with obstructive MG dysfunction (MGD) patients and control subjects using in vivo confocal microscopy (CM). Design: Prospective, controlled, single-center study. Participants: Twelve AKC patients (10 males, 2 females; mean age, 31.0±16.5 years), 12 obstructive MGD patients (7 males, 5 females; mean age, 37.6±5.6 years), and 26 control subjects (13 males, 13 females; mean age, 32.9±5.7 years) were recruited. No significant age or gender differences were observed between the 3 groups. Methods: All subjects underwent assessment of tear evaporation rate from the ocular surface (TEROS), slit-lamp examinations, tear break-up time (BUT) measurements, vital staining, Schirmer test I, meibography, MG expressibility, and CM examination of the MG (HRTII-RCM). Statistical analysis was performed using the Mann-Whitney test. Main Outcome Measures: The MG acinar unit density, inflammatory cell density, MG acinar unit longest diameter, MG acinar unit shortest diameter, and MG acinar unit area as observed by in vivo CM, MG drop-out, MG expressibility grading, tear stability, tear evaporation, and vital staining scores. Results: The TEROS values, mean BUT, vital staining scores, MG expressibility, and MG dropout grades were significantly worse in AKC patients compared with those in obstructive MGD patients and controls (P<0.05). The mean values of the CM parameters in AKC patients were significantly worse than those observed in the obstructive MGD patients and controls (P<0.001). Conclusions: Changes in MG in AKC patients seem to be more severe than in patients with obstructive MGD and controls. In vivo CM is a noninvasive, efficient tool in the assessment of MG status and ocular surface disease in AKC. Financial Disclosure(s): The authors have no proprietary or commercial interest in any of the materials discussed in this article.

AB - Purpose: To clarify meibomian gland (MG) alterations in atopic keratoconjunctivitis (AKC) patients and compare the findings with obstructive MG dysfunction (MGD) patients and control subjects using in vivo confocal microscopy (CM). Design: Prospective, controlled, single-center study. Participants: Twelve AKC patients (10 males, 2 females; mean age, 31.0±16.5 years), 12 obstructive MGD patients (7 males, 5 females; mean age, 37.6±5.6 years), and 26 control subjects (13 males, 13 females; mean age, 32.9±5.7 years) were recruited. No significant age or gender differences were observed between the 3 groups. Methods: All subjects underwent assessment of tear evaporation rate from the ocular surface (TEROS), slit-lamp examinations, tear break-up time (BUT) measurements, vital staining, Schirmer test I, meibography, MG expressibility, and CM examination of the MG (HRTII-RCM). Statistical analysis was performed using the Mann-Whitney test. Main Outcome Measures: The MG acinar unit density, inflammatory cell density, MG acinar unit longest diameter, MG acinar unit shortest diameter, and MG acinar unit area as observed by in vivo CM, MG drop-out, MG expressibility grading, tear stability, tear evaporation, and vital staining scores. Results: The TEROS values, mean BUT, vital staining scores, MG expressibility, and MG dropout grades were significantly worse in AKC patients compared with those in obstructive MGD patients and controls (P<0.05). The mean values of the CM parameters in AKC patients were significantly worse than those observed in the obstructive MGD patients and controls (P<0.001). Conclusions: Changes in MG in AKC patients seem to be more severe than in patients with obstructive MGD and controls. In vivo CM is a noninvasive, efficient tool in the assessment of MG status and ocular surface disease in AKC. Financial Disclosure(s): The authors have no proprietary or commercial interest in any of the materials discussed in this article.

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