In vivo imaging in humanized mice

H. Masuda, H. J. Okano, T. Maruyama, Y. Yoshimura, H. Okano, Y. Matsuzaki

研究成果: Chapter

9 被引用数 (Scopus)

抄録

The radiological modalities that are currently utilized as critical components in clinical medicine have also been adapted to small-animal imaging, among which are ultrasound imaging, X-ray computerized tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), and singlephoton emission computed tomography (SPECT). Optical imaging techniques such as bioluminescence imaging (BLI) and fluorescence imaging (FLI) are approaches that are commonly used in small animals. Longitudinal surveys of living (i.e., nonsacrificed) animal models with these modalities provide some clues for the development of clinical applications. The techniques are absolutely essential for translational research. However, there are currently few tools available with sufficient spatial or temporal resolution ideal for all experimental studies. In this chapter, we provide a rationale and techniques for visualizing target cells in living small animals and an overview of the advantages and limitations of current imaging technology. Finally, we introduce a humanized mouse and a novel in vivo imaging system that we have developed. We also discuss real-time observations of reconstructs and clinical manifestations.

本文言語English
ホスト出版物のタイトルHumanized Mice
編集者Tatsuji Nomura, Sonoko Habu, Takeshi Watanabe
ページ179-196
ページ数18
DOI
出版ステータスPublished - 2008 12 1

出版物シリーズ

名前Current Topics in Microbiology and Immunology
324
ISSN(印刷版)0070-217X

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

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