In vivo photodynamic inactivation of Psuedomonas aeruginosa in burned skin in rats

Akihiro Hirao, Shunichi Sato, Mitsuhiro Terakawa, Daizoh Saitoh, Nariyoshi Shinomiya, Hiroshi Ashida, Minoru Obara

    研究成果: Conference contribution

    1 被引用数 (Scopus)

    抄録

    Control of infection in wounds is critically important to avoid transition to sepsis; however, recent rise of drug-resistant bacteria makes it difficult. Thus, antimicrobial photodynamic therapy (APDT) has recently received considerable attention. In this study, we examined methylene blue (MB)-mediated photodynamic inactivation of Psuedomonas aeruginosa in rat burned skin. Two days after infection, the wound surface was contacted with a MB solution at different concentrations, and thereafter the wound was irradiated with cw 665-nm light at a constant power density of 250 mW/cm2 for different time durations. We obtained a two orders of magnitude decrease in the number of bacteria by PDT with a 2-h contact of 0.5-mM MB solution and a illumination of 480 J/cm2, demonstrating the efficacy of PDT against infection with Ps. aeruginosa in burns.

    本文言語English
    ホスト出版物のタイトルOptical Methods for Tumor Treatment and Detection
    ホスト出版物のサブタイトルMechanisms and Techniques in Photodynamic Therapy XIX
    DOI
    出版ステータスPublished - 2010 5 3
    イベントOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX - San Francisco, CA, United States
    継続期間: 2010 1 232010 1 25

    出版物シリーズ

    名前Progress in Biomedical Optics and Imaging - Proceedings of SPIE
    7551
    ISSN(印刷版)1605-7422

    Other

    OtherOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX
    CountryUnited States
    CitySan Francisco, CA
    Period10/1/2310/1/25

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Atomic and Molecular Physics, and Optics
    • Radiology Nuclear Medicine and imaging

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