In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse

Misa Suzuki-Anekoji, Atsushi Suzuki, Sz Wei Wu, Kiyohiko Angata, Keith K. Murai, Kazuhiro Sugihara, Tomoya O. Akama, Kay Hooi Khoo, Jun Nakayama, Michiko N. Fukuda, Minoru Fukuda

研究成果: Article

4 引用 (Scopus)

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Background: Chst10 transfers sulfate to glucuronic acid to form the HNK-1 antigen carried by glycoproteins and glycolipids in neurons and NK cells. Results: Chst10 transfers sulfate to glucuronidated steroid hormones, and Chst10-deficient mice exhibited subfertility. Conclusion: Subfertility in Chst10 null females is caused by a loss of steroid hormone dysregulation. Significance: This study identified a new regulatory mechanism mediated by sulfation of glucuronidated steroid.

元の言語English
ページ(範囲)5007-5016
ページ数10
ジャーナルJournal of Biological Chemistry
288
発行部数7
DOI
出版物ステータスPublished - 2013 2 15

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Suzuki-Anekoji, M., Suzuki, A., Wu, S. W., Angata, K., Murai, K. K., Sugihara, K., Akama, T. O., Khoo, K. H., Nakayama, J., Fukuda, M. N., & Fukuda, M. (2013). In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse. Journal of Biological Chemistry, 288(7), 5007-5016. https://doi.org/10.1074/jbc.M112.433474