In vivo roles of lysophospholipid receptors revealed by gene targeting studies in mice

Amy H. Yang, Isao Ishii, Jerold Chun

研究成果: Review article査読

80 被引用数 (Scopus)

抄録

Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are extracellular ligands for a family of G protein-coupled receptors (GPCRs), LPA1/2/3 and S1P1/2/3/4/5. Through coupling to multiple classes of G proteins and activating multiple signaling pathways, LPA/S1P receptors have been shown to be integral players for many essential cellular and physiological processes. Generation and analysis of mice deficient in each of LPA1, LPA2, S1P1, S1P2, and S1P3 have provided valuable information on the in vivo roles of these receptors. This review is focussed on expression patterns of each receptor gene in wild-type mice, targeted deletion approaches for generating mutant animals, main phenotypes of receptor-null mice, and alterations in signaling characteristics in receptor-deficient primary cells. Altogether, these data give insights to the importance of LPA/S1P receptors at the cellular and organismal level.

本文言語English
ページ(範囲)197-203
ページ数7
ジャーナルBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
1582
1-3
DOI
出版ステータスPublished - 2002 5月 23
外部発表はい

ASJC Scopus subject areas

  • 分子生物学
  • 細胞生物学

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