Inactivation of the pons blocks medullary-induced muscle tone suppression in the decerebrate cat

Jun Kohyama, Yuan Yang Lai, Jerome M. Siegel

研究成果: Article査読

23 被引用数 (Scopus)

抄録

The pontomedullary region is responsible for the reduction of muscle activity in rapid-eye-movement sleep and contributes to the control of muscle tone in waking. This study sought to clarify the nature of the interaction between the pontine and medullary reticular formation in mediating muscle tone suppression. The degree of medullary-induced neck muscle tone suppression in the decerebrate cat was assessed before and after microinjection of lidocaine into the pontine reticular formation. Medullary stimulation-induced suppression of neck muscle tone was blocked after pontine lidocaine microinjection. The maximum blockade was observed at 16.6 minutes on average after the injection, and recovery occurred within 45 minutes. We conclude that descending mechanisms from the medulla are not sufficient for the triggering of muscle tone suppression. A two-way interaction between the medulla and pons is hypothesized to play a crucial role in the control of muscle tone.

本文言語English
ページ(範囲)695-699
ページ数5
ジャーナルSleep
21
7
DOI
出版ステータスPublished - 1998 11 1
外部発表はい

ASJC Scopus subject areas

  • 臨床神経学
  • 生理学(医学)

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