Inactivation of tissue inhibitor of metalloproteinases by neutrophil elastase and other serine proteinases

Yasunod Okada, Shoji Watanabe, Isao Nakanishi, Jun ichi Kishi, Taro Hayakawa, Wieslaw Watorek, James Travis, Hideaki Nagase

研究成果: Article査読

159 被引用数 (Scopus)

抄録

Tissue inhibitor of metalloproteinases (TIMP) from cultured bovine dental pulp inhibits human rheumatoid synovial matrix metalloproteinase 3 (MMP-3) with a stoichiometry of 1:1 on a molar basis. Among the serine proteinases examined, human neutrophil elastase, trypsin and α-chymotrypsin destroyed the inhibitory activity of TIMP against MMP-3 by degrading the inhibitor molecule into small fragments. In contrast, the inhibitory activity of TIMP was not significantly reduced by the actions of cathepsin G, pancreatic elastase and plasmin. These data indicate that neutrophils which infiltrate tissues in various inflammatory conditions may play an important role in regulating TIMP activity in vivo through the action of neutrophil elastase.

本文言語English
ページ(範囲)157-160
ページ数4
ジャーナルFEBS Letters
229
1
DOI
出版ステータスPublished - 1988 2 29

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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